文献类型：期刊文献

英文题名：Essential oil of Angelica sinensis: A review of its extraction processes, phytochemistry, pharmacological effects, potential drug delivery systems, and applications

作者：Ge, Xiaoxiao[1];Zou, Junbo[1];Shi, Yajun[1];Guo, Dongyan[1];Zhao, Chongbo[1];Chen, Qin[1];Shao, Jing[2];Sun, Jing[1];Luan, Fei[1];Yang, Ming[3];Zhang, Xiaofei[1]

第一作者：Ge, Xiaoxiao

通信作者：Zhang, XF[1]

机构：[1]Shaanxi Univ Chinese Med, Sch Pharm, Century Ave, Xianyang 712046, Shaanxi, Peoples R China;[2]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China;[3]Jiangxi Univ Chinese Med, Sch Pharm, Nanchang 330004, Jiangxi, Peoples R China

第一机构：Shaanxi Univ Chinese Med, Sch Pharm, Century Ave, Xianyang 712046, Shaanxi, Peoples R China

通信机构：[1]corresponding author), Shaanxi Univ Chinese Med, Sch Pharm, Century Ave, Xianyang 712046, Shaanxi, Peoples R China.

年份：2025

卷号：18

期号：10

外文期刊名：ARABIAN JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001600830300001)】；

基金：This project has been supported by the National Key Research and Development Program of China (2021YFD1601004, 2023YFD1600402, 2023YFD1600403) ; Shaanxi Provincial Key Research and Development Program Project (2024CY-JJQ-36) ; Xi'an Science and Technology Plan Project (20231H-JSJ0-0007) ; Inner Mongolia Autonomous Region Science and Technology Program (2022YFSH0001) ; Qin Chuangyuan Traditional Chinese Medicine Industry Innovation Cluster Project (L2024-QCY-ZYYJJQ-X41) ; Science and Technology Programmer of xian New Area (DJK-2023-004) ; Shaanxi Provincial Traditional Chinese Medicine Science and Technology Innovation Team (TZKN-CXTD-03) ; Shaanxi Provincial Department of Science and Technology Project (2024 ZC-YYDP-110) ; Shaanxi Province Xianyang City Science and Technology Bureau Project (L2024-QCY-ZYYJJQ-X28) ; Shaanxi Provincial Administration of Traditional Chinese Medicine (ZYJXG-Y23005) ; National-Level High-Caliber Talent Innovation and Entrepreneurship Project; Key Technological Innovation Team for Industrialization of Aromatic Traditional Chinese Medicine Engineering Research Center of Traditional Chinese Shaanxi Medicine Aromatic Industry, Universities of Shaanxi Province; Key Discipline of High Level Traditional Chinese Medicine in Shaanxi Province, Traditional Chinese Medicine Processing.

语种：英文

外文关键词：Natural products; Extraction processes; Chemical compositions; Pharmacological effects; Applications

摘要：Essential oils have long been integral to various traditional healing systems for their medicinal properties, frequently preferred over chemical drugs due to chemical drugs reported adverse effects. Consequently, diverse plant sources have been explored for essential oil extraction. The essential oil of Angelica sinensis (EOAS) contributes significantly to its medicinal properties and is a critical quality control marker for its assessment. EOAS finds application in personal care products, perfumery, pharmaceuticals and food additives. A comprehensive literature search was performed using databases such as PubMed, ScienceDirect, Scopus, and Bentham. Keywords such as essential oil, EOAS and A. sinensis were employed to retrieve literature detailing therapeutic mechanisms and applications of herbal preparations. This review systematically outlines the pharmacological effects of EOAS on the cardiovascular and cerebrovascular systems, central nervous system (CNS), antioxidant properties, inflammation, and sedation. It details its roles in analgesia, antimicrobial activity, and asthma management. This manuscript further summarizes the drug delivery system, potential applications, extraction process, toxicity, contraindications, and chemical composition of EOAS. It critically assesses the limitations of current research in this field. EOAS exerts pharmacological effects in cardiovascular and cerebrovascular diseases, CNS diseases, inflammation, analgesia and sedation by improving microcirculation, scavenging ROS, activating endogenous antioxidants, activating Nrf2/ARE pathways, and enhancing endogenous antioxidant enzyme activity. It exerts a multimodal analgesic effect by inhibiting TRPV1 channel desensitization and modulating mu-opioid receptor activity in detail. In terms of antibacterial, EOAS can reduce fungal lipid and alginate content and change cell membrane permeability. In addition, he lowers IL-4 levels while increasing IL-10 and stabilizing T cells to alleviate asthma symptoms. This manuscript further summarizes Potential applications for EOAS such as j3-cyclodextrin inclusion complexes, liposomes, etc. This manuscript further summarizes potential applications of EOAS, such as j3-cyclodextrin complexes, liposomes, and others. We cover how to remove EOAS steam distillation, organic solvent extraction, and more. In addition, adverse reactions such as gastrointestinal discomfort and strong irritation can be present in EOAS applications. Its potential applications in baked goods, food packaging, insect repellents, crop fungicides.We also cover the main chemical constituents of EOAS such as ligustrum, n-butylbenzelene, j3-occiene, etc. This comprehensive review underscores the potential of EOAS as a natural and effective treatment for cardiovascular diseases, fungal infections, and inflammation. It advocates utilizing EOAS as a prospective raw material in developing new health-promoting products, such as green natural foods and food preservation packaging.