文献类型：期刊文献

中文题名：运脾法治疗小儿厌食症随机对照试验Meta分析

英文题名：Transporting the Spleen Method Meta-analysis in the Treatment of Infantile Anorexia Randomized Controlled Trial

作者：王鹏飞[1];蔺湘宁[1];张弢[1];王凤仪[1];王小荣[1]

第一作者：王鹏飞

机构：[1]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2017

卷号：13

期号：8

起止页码：63

中文期刊名：亚太传统医药

外文期刊名：Asia-Pacific Traditional Medicine

基金：国家自然科学基金项目(81360556)

语种：中文

中文关键词：运脾法;小儿厌食症;Meta分析;系统评价

外文关键词：Transporting the Spleen Method ; Infantile Anorexia;Meta Analysis System for Evaluation

摘要：目的:利用Meta分析方法对已发表的运脾法治疗小儿厌食症随机对照试验的疗效进行评价,为临床治疗小儿厌食症提供依据。方法:以运脾法、小儿厌食症、中医、中药等词制定检索策略。检索中文期刊网全文数据库(CNKI、万方数据库、维普数据库),收集近10年运用运脾法治疗小儿厌食症的随机对照试验。结果:共纳入7篇文献共1 022例患者,按照Jadad量表进行评分,其中低质量文献3篇^([5][6][9]),高质量4篇^([7][8][10][11])。低质量文献评分均为2分,高质量文献中2篇评价为3分,2篇评价为4分。进行合并性检验,选用RR指标,采用固定效应模型,结果显示纳入的文献具有统计学异质性(P<0.00001,I^2=77%),进行敏感性分析,对7篇文献进行仔细判读后,考虑到病例来源较广,区域性较大,存在种族差异,对治疗有效率影响较大,故排除此文献~[7]。将其余6篇^([5][6][9][8][10][11])文章临床有效率进行合并,效应量为RR=1.28[1.18,1.40](95%CI)(P<0.00001),有统计学意义。有3篇文章^([6[8][9])报道了治疗后证候积分表的变化,对上述文献进行了合并分析,采用随机效应模型,合并效应量有统计学意义(WMD=-6.11[-11.47,-0.74](95%CI)P=0.03)。有2篇^([5][9])报道了治疗前后D-木糖醇排泄率的变化,其中治疗组110例,对照组70例,结果显示具有统计学异质性(P=0.0010,I^2=72%),采用随机效应模型合并效应量无明显统计学意义(WMD=0.19[-0.02,0.40](95%CI)P=0.08)。结论:运脾法治疗小儿厌食症疗效显著,能明显改善小儿厌食症患者的临床症状。
Objective. To use the meta analysis method to the published transporting spleen method to evaluate the curative effect of treatment of infantile anorexia, provide the basis for clinical treatment of infantile anorexia. Methods：With the spleen method, in- fantile anorexia, Chinese medicine, Chinese medicine, such as word retrieval strategy. Retrieve the Chinese journal full-text database （CNKI）, a database of ten thousand, Wei database, collect almost 10 years using the method of transporting spleen randomized con- trolled trials for the treatment of infantile anorexia. Results： The participants included a total of 1022 patients, 7 documents shall be carried out in accordance with the Jadad scale score, low quality of 3[5][6][9] references, 4[7][8][10][11] papers with high quality. Low qual- ity score of 2 points, high quality of literature evaluation 2-3 points, evaluation 2-4 points. Consolidation test, choose RR index, by using the fixed effects model, results show that the heterogeneity of literature into statistically （P〈0. 00001, I2 =77%）, sensi- tivity analysis, after the careful reading of the literature of article 7, considering the case source wide, regional, eating habits, and racial differences, for greater influence on the treatment efficiency, eliminate[7] this literature. Clinical efficient merging, the rest6[5][6][9][8]][10][11] article effect size for the RR=1. 28 （95% CI） El. 18,1.40] （P〈0. 00001） was statistically significant, there are three articles reported the change of the syndrome integral table after treatment, the above3[6][8][9] articles merged analysis, by using the random effects model, merge effect quantity was statistically significant （WMD [11.47, 0. 74] = 6. 11 （95% CI） P=0.03）, there are 2[5][9] report the D- stolidity excretion rate changes before and after the treatment, the treatment group 110 cases, control group 70 examples, the results show statistically heterogeneity （P~ 0. 0010, I2 = 72 %）, by using the random effects model com- bined effect quantity has no obvious statistical significance （WMD [0. 02, 0. 40]- 0. 19 （95 %CI） P= 0. 08）. Conclusion： The spleen method to treat infantile anorexia curative effect significantly, can significantly improve the clinical symptoms of patients with infantile anorexia.