文献类型：期刊文献

英文题名：CTGF: The remodeler of the tumor immune microenvironment (Review)

作者：Zhao, Ying[1];Han, Li[2];Wu, Qingyu[2];Li, Haiying[3];Dai, Fuhong[4]

第一作者：赵英

通信作者：Li, HY[1];Dai, FH[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Publ Hlth, Dept Clin Lab Diag, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Prov Hosp, Dept Tumor Intervent, 204 Donggang West Rd, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Dept Clin Lab Diag, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Tumor Intervent, 204 Donggang West Rd, Lanzhou 730000, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2026

卷号：56

期号：4

外文期刊名：ONCOLOGY REPORTS

收录：;Scopus(收录号：2-s2.0-105046368934);WOS:【SCI-EXPANDED(收录号:WOS:001841132000001)】；

基金：This work was supported by the Intramural Research Fund Project of Gansu Provincial Hospital (grant no. 25GSSYE-2).

语种：英文

外文关键词：connective tissue growth factor; tumor immune microenvironment; cancer-associated fibroblasts; epithelial-mesenchymal transition; extracellular matrix; immune evasion

摘要：The tumor immune microenvironment (TIME) is the key determinant of limited efficacy and acquired resistance to cancer immunotherapy across human malignancies. In this context, connective tissue growth factor (CTGF) has been implicated in multiple TIME-related processes, including tumor-cell phenotypic regulation, extracellular matrix (ECM) remodeling, immune-cell modulation, and cytokine-network alterations. Collectively, this suggests that CTGF may participate in coordinated crosstalk among structural, signaling, and immune components of the TIME. Empirical evidence supports roles for CTGF in selected tumor and stromal settings. However, its broader contribution to coordinated TIME remodeling remains partly inferential and requires further experimental validation. Where present, such coordinated effects may impair antitumor immune recognition and promote tumor-cell survival within specific tumor microenvironmental settings. The present review summarizes the core mechanisms of CTGF-mediated TIME remodeling and outlines the translational potential of CTGF-targeted combination immunotherapies and key research priorities to advance its clinical translation.