文献类型：期刊文献

中文题名：干细胞在治疗抑郁症中的作用

英文题名：Role of stem cells in depression therapy

作者：蒋如如[1,2,3];李欣(综述)[1,2];哈小琴(审校)[1,2]

第一作者：蒋如如

机构：[1]甘肃中医药大学临床医学院,甘肃兰州730030;[2]中国人民解放军联勤保障部队第九四〇医院检验科,甘肃兰州730050;[3]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

第一机构：甘肃中医药大学临床医学院

年份：2020

卷号：33

期号：12

起止页码：1450

中文期刊名：中国生物制品学杂志

外文期刊名：Chinese Journal of Biologicals

收录：CSTPCD;;Scopus;CSCD:【CSCD_E2019_2020】；

基金：甘肃省重点研发计划项目(17YF1FA135)。

语种：中文

中文关键词：抑郁症;神经干细胞;诱导多能干细胞;细胞治疗

外文关键词：Depression;Neural stem cells(NSCs);Induced pluripotent stem cells(i PSCs);Cell therapy

摘要：抑郁症是世界范围内常见的精神疾病,心理及药物治疗是抑郁症的常用治疗方法,但治疗后期大部分抑郁症患者对治疗产生抗性,目前迫切需要一种新型抗抑郁治疗方式来改善这一现状。近年来,随着干细胞在疾病建模及细胞治疗方面的应用,神经干细胞(neural stem cell,NSC)及诱导多能干细胞(induced pluripotent stem cell,i PSC)模拟人体神经系统的技术也越来越成熟,对抑郁症的发病机制、病理生理学及抗抑郁药物的作用机制也得到了更深的了解。本文就抑郁症的发病机制、NSC及i PSC构建抑郁症模型和细胞治疗策略作一综述,为抗抑郁治疗提供新的认知。
Depression is a common mental disorder worldwide.Psychological treatments and antidepressant medication are the usual therapies for depression.However,since most of the patients are resistant to treatments at the late stage of therapy,it is urgent to develop a novel method for depression therapy.In recent years,with the wide application of stem cells in establishment of disease model and cell therapy,the technology of mimicking human neural system in vitro by neural stem cells(NSCs)and induced pluripotent stem cells(i PSCs)is more and more mature,which allows a better understanding of depression in pathogenesis,pathophysiology as well as the mechanism of antidepressant medicines.This paper reviews the pathogenic mechanism of depression as well as the strategies for depression modelling and cell therapy by NSCs and i PSCs,so as to provide a new understanding of antidepressant treatment.