文献类型：期刊文献

英文题名：Br?nsted Acid-Catalyzed Intramolecular Tandem Double Cyclization of γ-Hydroxy Acetylenic Ketones with Alkynes into Naphtho[1,2-b]furan-3-ones

作者：Zhang, Sen[1];Zhu, Hai-Tao[1];Xi, Jia-Jun[1];Wang, San-Bao[1];Chang, Xin[1];Shen, Cheng-Ping[1];Feng, Yue[1];Zhang, Zhao-Yang[1];Zhao, Meng-Ting[1];Zhang, Li-Kun[1];Li, Mi[2];Jin, Xiaojie[2];Zhou, An-Xi[3];Zhou, Ni-Ni[1]

第一作者：Zhang, Sen

通信作者：Zhu, HT[1];Zhou, NN[1];Jin, XJ[2]

机构：[1]Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Shannxi Key Lab Phytochem, Baoji 721013, Peoples R China;[2]Gansu Univ Chinese Med, Gansu Univ Key Lab Mol Med & Chinese Med Prevent &, Lanzhou 730000, Peoples R China;[3]Shangrao Normal Univ, Key Lab Appl Organ Chem Higher Inst Jiangxi Prov, Shangrao 334000, Peoples R China

第一机构：Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Shannxi Key Lab Phytochem, Baoji 721013, Peoples R China

通信机构：[1]corresponding author), Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Shannxi Key Lab Phytochem, Baoji 721013, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Gansu Univ Key Lab Mol Med & Chinese Med Prevent &, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：89

期号：3

起止页码：1633

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001157569400001)，CCR-EXPANDED(收录号:WOS:001157569400001)】；

基金：The authors gratefully acknowledge the financial support of this work by the Shaanxi National Science Foundation (2021JQ-802), the Shannxi Provincial Department of Education Project (21JK0476), the Innovation Capability Support Program of Shaanxi (2022TD-63), and the Innovation R&D Team of BUAS on Qinling Medicinal Plants and Functional Organic Molecules.

语种：英文

摘要：A metal-free and atom-economic route for the synthesis of naphtho-[1,2-b]-furan-3-ones has been realized via p-TsOH center dot H2O-catalyzed intramolecular tandem double cyclization of gamma-hydroxy acetylenic ketones with alkynes in formic acid. The benzene-linked furanonyl-ynes are the key intermediates obtained by the scission/recombination of C-O double bonds. Further, the structural modifications of the representative product were implemented by reduction, demethylation, substitution, and [5 + 2]-cycloaddition.