文献类型：期刊文献

英文题名：Case Report: A very rare case of diffuse large B-cell lymphoma with cardiac and ovarian involvement

作者：Du, Yadan[1,2];Tian, Yuting[2];Chen, Yawen[2];Cheng, Shuaihua[2];Gao, Jianping[1]

第一作者：Du, Yadan

通信作者：Gao, JP[1]

机构：[1]Gansu Prov Hosp, Dept Surg Oncol, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China

第一机构：Gansu Prov Hosp, Dept Surg Oncol, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Surg Oncol, Lanzhou, Peoples R China.

年份：2025

卷号：15

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-105008917620);WOS:【SCI-EXPANDED(收录号:WOS:001514471100001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the Youth Fund of Gansu Provincial Hospital (Grant No. 20GSSY4-13), Gansu Provincial Hospital (Grant No. 22GSSYD-16) and Natural Science Foundation of Gansu Province (Grant No. 25JRRA873).

语种：英文

外文关键词：diffuse large B-cell lymphoma; non-Hodgkin lymphoma; heart; ovary; case report

摘要：Background Diffuse large B-cell lymphoma (DLBCL) is the most prevalent type of aggressive lymphoma, commonly spreading to sites such as the lymph nodes, spleen, bone marrow, liver, lungs, and central nervous system. However, metastasis to the heart and ovaries is relatively uncommon.Case Description A 63-year-old woman visited the hospital with abdominal pain and bloating, but showed none of the typical signs of lymphoma. Imaging scans revealed abnormal masses in both the pericardium and ovaries. A biopsy confirmed it was DLBCL, presenting in the rare form of simultaneous spread to the heart lining and ovaries. During the course of illness, she also developed atrial arrhythmia. Doctors adopted a phased treatment approach: four cycles of R-CEOD chemotherapy led to a noticeable reduction in the heart tumor and improvement in her heart rhythm. This was followed by four cycles of R-CHOP, which further shrank the cardiac lesion and cleared the abdominal tumors completely. The treatment was well tolerated, and at a three-month follow-up, there was no sign of recurrence. Her heart function remained stable, with a left ventricular ejection fraction (LVEF) of 60%.Conclusion This case highlights the importance of early detection of atypical metastases in DLBCL through a combination of various imaging and pathological tests. Additionally, personalized treatment strategies may contribute to better patient outcomes.