文献类型：期刊文献

英文题名：Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives

作者：Shi, Liangliang[1];Wang, Shuaizhe[1];Zhang, Shangzu[1];Wang, Jiawei[1];Chen, Yaping[1];Li, Yangyang[1];Liu, Zhiwei[1];Zhao, Sichen[1];Wei, Benjun[1,3];Zhang, Liying[1,2]

第一作者：Shi, Liangliang

通信作者：Wei, BJ[1];Zhang, LY[1];Zhang, LY[2];Wei, BJ[3]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]Key Lab Tradit Chinese Med Explorat & Innovat Tran, Lanzhou, Peoples R China;[3]Key Lab Dunhuang Med & Transformat Prov & Minister, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Key Lab Tradit Chinese Med Explorat & Innovat Tran, Lanzhou, Peoples R China;[3]corresponding author), Key Lab Dunhuang Med & Transformat Prov & Minister, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：396

期号：11

起止页码：2843

外文期刊名：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85162245057);WOS:【SCI-EXPANDED(收录号:WOS:001015575600004)】；

基金：National Natural Science Foundation of China (82260893), project supported by Gansu Provincial Department of Education (2022B-116), Gansu Province Industrial Support and Guidance Special Project (2020C-15), Natural Science Foundation of Gansu Province (20JR5RA180), Gansu Provincial Key Laboratory of Traditional Chinese Medicine Prescription Drug Mining and Innovation Transformation Open Fund (zyzx-2020-11), "Innovation Star" Project of Outstanding Graduate Students in Gansu Province (2022 CXZX-735).

语种：英文

外文关键词：Cepharanthine; Derivatives; Molecular mechanism; Anti-inflammatory; Antiviral; Antitumor; Immunity

摘要：Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid compound found in plants of the Stephania genus, which has biological functions such as regulating autophagy, inhibiting inflammation, oxidative stress, and apoptosis. It is often used for the treatment of inflammatory diseases, viral infections, cancer, and immune disorders and has great clinical translational value. However, there is no detailed research on its specific mechanism and dosage and administration methods, especially clinical research is limited. In recent years, CEP has shown significant effects in the prevention and treatment of COVID-19, suggesting its potential medicinal value waiting to be discovered. In this article, we comprehensively introduce the molecular structure of CEP and its derivatives, describe in detail the pharmacological mechanisms of CEP in various diseases, and discuss how to chemically modify and design CEP to improve its bioavailability. In summary, this work will provide a reference for further research and clinical application of CEP.