文献类型：期刊文献

中文题名：响应面法优化复方当归妇炎微灌肠剂的提取工艺

英文题名：Optimization of Extraction Technology of Compound Angelica Fuyan Micro-enema by Response Surface Methodology

作者：李仲葓[1];余晓晖[1];梁琦虎[2];张立军[2]

第一作者：李仲葓

机构：[1]甘肃中医药大学教学实验实训中心;[2]甘肃中医药大学药学院

第一机构：甘肃中医药大学教学实验实训中心

年份：2018

卷号：34

期号：2

起止页码：147

中文期刊名：解放军药学学报

外文期刊名：Pharmaceutical Journal of Chinese People's Liberation Army

收录：CSCD:【CSCD_E2017_2018】；

基金：兰州市科技局重点项目;No.2014-1-145

语种：中文

中文关键词：复方当归妇炎微灌肠剂;响应面法;阿魏酸;芍药苷

外文关键词：compound angelica fuyan micro enema;response surface methodology;ferulic acid;paeoniflorin

摘要：目的优化复方当归妇炎微灌肠剂的提取工艺。方法采用单因素和响应面分析方法,以料液比、浸泡时间、煎煮时间为自变量,阿魏酸、芍药苷含量、浸膏得率和总评归一化值为因变量,利用响应面法分析自变量对因变量的影响,确定最优条件进行试验验证。结果最佳提取工艺条件为加10倍量水浸泡22min,煎煮2次,每次21min。在此条件下,预测值和测定值偏差均<5%,与模型拟合程度较好。结论优化的复方当归妇炎微灌肠剂提取工艺方法科学、简便,具有很好的实用价值,为复方当归妇炎微灌肠剂的提取提供了参考依据。
Objective To optimize the extraction technology of compound Angelica fuyan micro enema.Methods Using single factor and response surface analysis method,the solid-liquid ratio,soaking time and decocting time were taken as independent variables while the content of ferulic acid,paeoniflorin,dry extract rate and general normalized value were taken as dependent variables.The response surface methodology（RSM）was used to estimate the relationships between the dependent and independent variables,and to validate the optimal formulation.Results The optimal conditions involved adding 10 times as much water,soaking for 22 min,and decocting twice,each time 21 min.Under these conditions,the measured value was consistent with the predicated value with RSD5%.Conclusion The preparation technology of compound Angelica fuyan micro enema is optimized,which is simple and feasible for the extraction of compound Angelica fuyan micro enema.