文献类型：期刊文献

中文题名：知柏地黄丸对性早熟模型大鼠FSH、T水平的影响

英文题名：Action of ZhiBai DiHuang Pill on the Levels of FSH and T of Rats with Sexual Precocity

作者：吴丽萍[1];李玉霞[1];尚菁[2];吕晓武[2]

第一作者：吴丽萍

机构：[1]甘肃中医学院附属医院,甘肃兰州730020;[2]甘肃中医学院

第一机构：甘肃中医药大学第二附属医院

年份：2013

卷号：26

期号：11

起止页码：10

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃省中医药管理局科研基金资助项目(编号2007-CZK-40)

语种：中文

中文关键词：性早熟;知柏地黄丸;卵泡刺激素;血清睾酮;大鼠

外文关键词：sexual precocity; ZhiBai DiHuang pill; follicle-stimulating hormone; serum testosterone; rat

摘要：目的:探讨知柏地黄丸对雌性真性性早熟大鼠垂体分泌的卵泡刺激素(FHS)、性腺分泌的睾酮(T)水平的影响。方法:将26日龄雌性SPF级SD大鼠50只随机分为5组,每组10只。采用N-甲基-D-天冬氨酸(NMDA)方法诱发建立性早熟动物模型,分别用放免法测定血清FSH、T水平。结果:模型组与空白组、知柏地黄丸大、中剂量组大鼠血清FSH及T水平比较,差异均有统计学意义(P<0.05),说明知柏地黄丸可降低性早熟大鼠血清FSH,T水平;小剂量组与大、中剂量组血清FSH,T水平比较,差异有统计学意义(P<0.05),说明知柏地黄丸调节性早熟大鼠血清FSH,T水平存在量效关系。结论:知柏地黄丸可抑制NMDA诱发雌性大鼠性早熟的发生及模型大鼠血清性激素FSH,T水平的表达。推测知柏地黄丸对模型大鼠下丘脑-垂体-性腺轴有调节作用。
Objective： To discuss the action ofZhiBai DiHuang pill on testosterone （T） and follicle-stimulating hormone （FSH） of rats suffering from sexual precocity. Method： All 50 rats were randomized into five groups, ten rats each group. Animal models were established by the method ofN-methyl-D-aspartate （NMDA）. The levels ofT and FSH were detected through radioimmtmoassay respectively. Result： The difference had statistical meaning in the levels of FSH and T from the comparison between model group and blank group, high dosage and low dosage groups ofZhiBai DiHuang pill （P〈0.05）. It demonstrated that ZhiBai DiHuang pill could lower the levels of T and FSH; the difference had statistical meaning in the levels of T and FSH when low dosage group was compared with high and moderate dosage groups of ZhiBai DiHuang pill （P〈0.05）, it presented that ZhiBai DiHuang pill and regulating the levels of T and FSH showed the dose-effect relationship. Conclusion： ZhiBai DiHuang pill could inhibit the incidence of sexual precocity in female rat caused by NMDA and the expressions of T and FSH of rat model. We speculate that ZhiBai DiHuang pill could regulate hypothalamic-pituitary-gonadal axis of model rat.