文献类型：期刊文献

中文题名：大黄及其活性成分抗炎作用及机制的研究进展

英文题名：Research progress on anti-inflammatory effects and mechanism of Rhei Radix et Rhizoma and its active components

作者：曹强[1];郭亚菲[1];叶蕾蕾[1];张成园[1];寇仁博[1];郭玫[1,2]

第一作者：曹强

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省高校中(藏)药化学与质量研究省级重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：53

期号：22

起止页码：7285

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然基金联合基金重点项目(U21A20412);甘肃省自然科学基金项目(21JR7RA558);甘肃省教育厅“双一流”科研重点项目(GSSYLXM-05);甘肃中医药大学研究生创新基金(2022CX86)。

语种：中文

中文关键词：大黄;抗炎;急性胰腺炎;脓毒症;关节炎;作用机制;大黄素;大黄酸;大黄酚;芦荟大黄素

外文关键词：Rhei Radix et Rhizoma;anti-inflammatory;acute pancreatitis;sepsis;arthritis;mechanism of action;emodin;rhein;chrysophanol;aloe emodin

摘要：大黄为蓼科植物掌叶大黄Rheum palmatum、唐古特大黄R. tanguticum或药用大黄R. officinale的干燥根和根茎,具有泻下攻积、清热泻火、凉血解毒、逐瘀通经、利湿退黄之功。近年来研究发现大黄及其活性成分大黄素、大黄酸、大黄酚、芦荟大黄素等具有良好的抗炎、解热镇痛、抗肿瘤等活性。对大黄及其活性成分在治疗急性胰腺炎、脓毒症、关节炎等炎症性疾病的作用及机制的研究进展进行综述,以期为其在防治炎症疾病中的深入研究及开发应用提供参考。
Dahuang(Rhei Radix et Rhizoma, RRR) is the dry root and rhizome of the polygonum family plant Rheum palmatum, R.tanguticum or R. officinale, which has the functions of purgative accumulation, clearing away heat and fire, cooling blood and detoxifying, removing blood stasis and channeling meridian, excreting dampness and anti-icteric.In recent years, it has been found that RRR and its active components emodin, rhein, chrysophanol and aloe emodin have good anti-inflammatory, antipyretic,analgesic and antitumor activities. In this paper, the effects and mechanisms of RRR and its active components in the treatment of acute pancreatitis, sepsis, arthritis and other inflammatory diseases were reviewed, in order to provide a reference for the further research and development of its application in the prevention and treatment of inflammatory diseases.