文献类型：期刊文献

英文题名：Pharmacokinetics and tissue distribution of emodin loaded nanoemulsion in rats

作者：Shi, Yanbin[1];Li, Jincheng[1];Ren, Yuan[2];Wang, Haiqin[1];Cong, Zhaotong[1];Wu, Guotai[2];Du, Lidong[2];Li, Huili[1];Zhang, Xiaoyun[1]

第一作者：Shi, Yanbin

通信作者：Shi, YB[1]

机构：[1]Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Key Lab TCM Pharmacol & Toxicol Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.

年份：2015

卷号：30

起止页码：242

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：;Scopus(收录号：2-s2.0-84949545440);WOS:【SCI-EXPANDED(收录号:WOS:000367773500028)】；

基金：The authors acknowledge financial support from Key Laboratory of TCM Pharmacology and Toxicology of Gansu Province (ZDSYS-KJ-2013-005), Natural Science Grant of Gansu (145RJZA026), and Agricultural Biotechnology Research and Development Project of Gansu (GNSW-2013-14), P.R. China.

语种：英文

外文关键词：Emodin loaded nanoemulsion; Pharmacokinetics; Tissue distribution

摘要：Emodin, a natural product originated from radix et rhizoma Rhei, is a potential agent for anti-constipation, anti-inflammation, anti-cancer and so on. In this paper, a simple, economic and sensitive HPLC-FD method was developed and validated for the determination of emodin in rat plasma and tissue homogenates after oral administration of emodin loaded nanoemulsion (EMO-NE). Simultaneously, the pharmacokinetics of EMO-NE and emodin suspension were investigated so as to embody advantages of EMO-NE. AUC(0-infinity), C-max, t(1/2) and MRT0-infinity, of emodin-loaded nanoemulsion were respectively 2.37, 1.62, 3.99 and 2.39-fold higher than those of emodin suspension. Meanwhile, EMO-NE decreased the clearance rate of emodin more than double that of emodin suspension. Thus, it can be assumed that EMO-NE can effectively improve the bioavailability of emodin and prolong in vivo mean residence time via oral administration. All tested tissues of rats were found to retain parent drug for 48 h following a single oral dose of EMO-NE. The amount of emodin was the highest in the liver, and then lung, kidney, heart or spleen, and lowest in the brain. However, the mean residence time of emodin in the brain was the longest, almost two-fold longer than that in the other tissues. (C) 2015 Elsevier B.V. All rights reserved.