文献类型：期刊文献

中文题名：肾素-血管紧张素系统在高血压抑郁中的研究进展

英文题名：Research progress of renin-angiotensin system in hypertensive depression

作者：沈路凡[1,2];王晓科[1,2];王鸿[1,2];张玲娜[1,2];李嘉玮[1,2];路玉媛[1,2];田姣[1,2];康万荣[1,3];杨阿妮[4];伊琳[1,2]

第一作者：沈路凡

机构：[1]甘肃中医药大学中西医结合学院;[2]甘肃省中医药防治慢性疾病重点实验室;[3]甘肃省中药药理与毒理学重点实验室;[4]甘肃省中医院心血管病一科,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2025

卷号：41

期号：9

起止页码：1629

中文期刊名：中国药理学通报

外文期刊名：Chinese Pharmacological Bulletin

收录：;北大核心:【北大核心2023】；

基金：甘肃省中医药科研项目(No GZKP-2023-40);甘肃省高校教师创新基金项目(No 2025A-111);甘肃省科技计划青年科技基金(No 25JRRA935)。

语种：中文

中文关键词：肾素-血管紧张素系统;高血压;抑郁;共病;机制;综述

外文关键词：renin-angiotensin system;high blood pressure;depression;co-morbidity;mechanisms;review

摘要：随着生物-心理-社会医学模式的建立,无论社会因素还是心理因素在疾病的发生发展及治疗过程中都起到了重要的作用。高血压是我国常见的慢性多发疾病,患者常并发抑郁等情绪障碍,二者相互作用,致使不良预后风险显著增加。当前研究表明,高血压与抑郁症之间存在双向促进的联系,且在发病机制方面具有部分共性,然而,其共病的具体机制仍未得到充分阐释。肾素-血管紧张素系统(renin-angiotensin system,RAS)在高血压及抑郁等情绪调控中均起重要作用,它由两条相互拮抗的通路组成,通过血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2)维持平衡。因此,该文就RAS对高血压、抑郁以及共病状态下的关联及作用机制作一综述,以期为高血压抑郁提供新的治疗思路。
With the establishment of bio-psycho-social medical model,both social and psychological factors play an important role in the occurrence,development and treatment of diseases.Hypertension is a common chronic multiple disease in China,and patients are often complicated with depression and other emotional disorders.The interaction between hypertension and depression significantly increases the risk of poor prognosis.Current studies have shown a bidirectional promoting relationship between hypertension and depression,and they have some common pathogenesis.However,the specific mechanism of their comorbidity has not been fully elucidated.Renin-angiotensin system(RAS)plays an important role in the regulation of hypertension and depression and other emotions.It is composed of two antagonistic pathways.The balance is maintained by angiotensin-converting enzyme 2(ACE2).Therefore,this article reviews the relationship and mechanism of RAS in hypertension,depression and comorbid states,in order to provide new treatment ideas for hypertension and depression.