文献类型：期刊文献

英文题名：Research Progress on the Mechanism of the SFRP-Mediated Wnt Signalling Pathway Involved in Bone Metabolism in Osteoporosis

作者：An, Fangyu[1];Song, Jiayi[2];Chang, Weirong[2];Zhang, Jie[2];Gao, Peng[2];Wang, Yujie[3];Xiao, Zhipan[3];Yan, Chunlu[3]

第一作者：安方玉

通信作者：Yan, CL[1]

机构：[1]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：66

期号：5

起止页码：975

外文期刊名：MOLECULAR BIOTECHNOLOGY

收录：;EI(收录号：20240215365203);Scopus(收录号：2-s2.0-85181964910);WOS:【SCI-EXPANDED(收录号:WOS:001138394100002)】；

基金：This review gets grants from the National Natural Science Foundation of China (Grant No.82060872), the Scientific Research Program of Gansu Chinese Medicine Bureau (Grant GZKP-2023-39, and GZKP-2023-63), Research and Reform Project of Graduate Education and Teaching at Gansu University of Chinese Medicine (Grant 15), Teaching Research and Reform Project of Gansu University of Chinese Medicine (Grant YBXM-202332, and ZHXM-202307), and Gansu Province Higher Education Youth Doctoral Fund Project (Grant No. 2022QB-091)

语种：英文

外文关键词：Osteoporosis; SFRP5; Bone metabolism; Wnt signalling pathway; Molecular mechanism

摘要：Osteoporosis (OP) is a metabolic bone disease linked to an elevated fracture risk, primarily stemming from disruptions in bone metabolism. Present clinical treatments for OP merely alleviate symptoms. Hence, there exists a pressing need to identify novel targets for the clinical treatment of OP. Research indicates that the Wnt signalling pathway is modulated by serum-secreted frizzled-related protein 5 (SFRP5), potentially serving as a pivotal regulator in bone metabolism disorders. Moreover, studies confirm elevated SFRP5 expression in OP, with SFRP5 overexpression leading to the downregulation of Wnt and beta-catenin proteins in the Wnt signalling pathway, as well as the expression of osteogenesis-related marker molecules such as RUNX2, ALP, and OPN. Conversely, the opposite has been reported when SFRP5 is knocked out, suggesting that SFRP5 may be a key factor involved in the regulation of bone metabolism via the Wnt signalling axis. However, the molecular mechanisms underlying the action of SFRP5-induced OP have yet to be comprehensively elucidated. This review focusses on the molecular structure and function of SFRP5 and the potential molecular mechanisms of the SFRP5-mediated Wnt signalling pathway involved in bone metabolism in OP, providing reasonable evidence for the targeted therapy of SFRP5 for the prevention and treatment of OP.