文献类型：期刊文献

中文题名：巨噬细胞极化在假体周围骨溶解中的作用:研究现状和进展

英文题名：Role of macrophage polarization in periprosthetic osteolysis: its research status and advance

作者：巩栋[1,2];甄平[1];王荣[2]

第一作者：巩栋

机构：[1]解放军兰州军区兰州总医院骨科,甘肃省兰州市730000;[2]甘肃中医药大学,甘肃省兰州市730000

第一机构：解放军兰州军区兰州总医院骨科,甘肃省兰州市730000

年份：2018

卷号：22

期号：7

起止页码：1120

中文期刊名：中国组织工程研究

外文期刊名：Chinese Journal of Tissue Engineering Research

收录：CSTPCD;;北大核心:【北大核心2017】；

基金：国家自然科学基金资助项目(81371983)~~

语种：中文

中文关键词：巨噬细胞;关节成形术;骨质溶解;组织工程

外文关键词：Macrophages;Arthroplasty;Osteolysis;Tissue Engineering

摘要：背景:巨噬细胞是一群表型和功能均具有高度异质性的免疫细胞,在不同的组织微环境、不同病理条件下,可极化成不同的表型,即促炎的M1型巨噬细胞(经典活化的巨噬细胞)和抗炎的M2型巨噬细胞(替代活化的巨噬细胞)。研究发现巨噬细胞极化在假体周围骨溶解中具有重要作用。目的:对巨噬细胞极化概念、与骨溶解的关系以及相关治疗方式的研究现状和进展做一综述。方法:计算机检索Pub Med和CNKI数据库中1999年1月至2017年3月有关巨噬细胞极化和假体周围骨溶解的文章,排除其中与巨噬细胞极化研究无关的文章,中文检索词为"巨噬细胞极化,磨损颗粒,骨溶解",英文检索词为"macrophage polarization,wear particles,osteolysis"。结果与结论:(1)人工关节置换术后产生磨损颗粒诱导骨溶解的发生与巨噬细胞关系密切,但是从巨噬细胞极化这一角度所做研究还相对较少,大多在体外观察和实验阶段;(2)现今研究主要表明巨噬细胞可在磨损颗粒和细胞因子的刺激下向不同的表型极化,在假体周围主要极化为M1型,并且某些细胞因子可诱巨噬细胞向具有抑制炎症的M2型极化,具有广阔治疗前景,而相关具体机制仍然不清楚,需不断探究。
BACKGROUND:In terms of both phenotype and function,macrophages have remarkable heterogeneity.In respond to various environmental cues or under different pathophysiologic conditions,macrophages can be polarized into different phenotypes,that is,pro-inflammatory M1 phenotypes(classical activated marcrophage)or anti-inflammatory M2 phenotypes(alternative activated marcrophage).Macrophage polarizatinton has been found to play an important role in periprosthetic osteolysis.OBJECTIVE:To summarize the research status and new progress of the concept of macrophage polarization,the relationship between osteolysis as well as treatment methods of osteolysis.METHODS:A computer-based online retrieval was performed for the literature concerning macrophage polarization and periprosthetic osteolysis in PubMed and CNKI databases published from January 1999 to March 2017.Unrelated researches on macrophage polarization were excluded.The keywords were“macrophage polarization,wear particles,and osteolysis”in English and Chinese,respectively.RESULTS AND CONCLUSION:(1)The periprosthetic osteolysis after artifical joint replacement has a close relationship with macrophage,but few studies have been carried out from the respect of macrophage polarization.Most of researches are still on in vitro observation or experimental stage.(2)Current researches mainly show that macrophages can be polarized into different phenotypes by stimulation of wear particles and cytokines,the peri-implant macrophage phenotype has M1 characteristics and some cytokines can induce macrophages polarization to M2 type with anti-inflammatory characteristics.This conclusion has a broad prospect,but the related mechanisms still remain unclear,which need a further exploration.