文献类型：期刊文献

英文题名：Multimodality treatment on gastric cancer with liver metastasis: case report

作者：Li, Mengnan[1];Wang, Gongchen[1];Chen, Lianyu[2];Zhuang, Liping[2];Chen, Hao[2]

第一作者：李梦楠

通信作者：Wang, GC[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Med Oncol, Lanzhou, Peoples R China;[2]Fudan Univ, Shanghai Canc Ctr, Dept Integrat Oncol, Shanghai, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Med Oncol, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2025

卷号：15

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-105022099027);WOS:【SCI-EXPANDED(收录号:WOS:001614812600001)】；

基金：The author(s) declare financial support was received for the research and/or publication of this article. The study was funded by Gansu Science and Technology Commission (18JR2FA001; 22YF7FA102).

语种：英文

外文关键词：immune checkpoint inhibitors; gastric cancer; liver metastasis; cryoablation; case report

摘要：Background Advanced gastric cancer has a devastating prognosis, However, the optimal treatment for gastric cancer patients with multiple liver metastases(GCLM) remains yet to be fully elucidated. Cryoablation is a novel therapeutic approach that has the potential to induce tumor necrosis and elicit anti-tumor immune responses.Case presentation A 44-year-old male was diagnosed with advanced gastric adenocarcinoma. Despite undergoing multiple lines of systemic therapy and repeated locoregional treatments, the patient exhibited rapid tumor progression. Subsequent treatment with PD-1 inhibitors demonstrated limited efficacy. However, following the innovative application of cryoablation to eradicate a more significant lesion within the liver metastases, the patient achieved a partial response and experienced 15 months of progression-free survival (PFS) with the combined use of PD-1 inhibitors and chemotherapy at the time of this report.Conclusion Cryoablation combined with immunotherapy may provide potential benefits for specific patients and offer a meaningful therapeutic strategy for patients with advanced gastric cancer and liver metastases, which is worthy of further research.