文献类型：期刊文献

英文题名：Prenatal exposure to vanadium and lead and its impact on the risk of congenital heart defects in neonates: evidence from the Lanzhou Birth Cohort

作者：Wei, Ying[1];Sun, Jianhao[1,2];Wu, Zhenzhen[1];Teng, Liangsen[3];Huang, Jie[1,4];Jiao, Xinjuan[5];Dang, Yun[1];Zhao, Xiaoli[1];Zhang, Ying[1];Tuo, Shumei[1];Mao, Baohong[1];Liu, Qing[1]

第一作者：Wei, Ying

通信作者：Mao, BH[1];Liu, Q[1]

机构：[1]Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China;[2]Yangzhou Univ, Inst Translat Med, Med Coll, Yangzhou, Peoples R China;[3]Youjiang Med Univ Nationalities, Coll Clin Med, Baise, Peoples R China;[4]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Peoples R China;[5]Qingyang Second Peoples Hosp, Qingyang, Peoples R China

第一机构：Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：14

外文期刊名：FRONTIERS IN PUBLIC HEALTH

收录：;Scopus(收录号：2-s2.0-105034554960);WOS:【SSCI(收录号:WOS:001730025000001)，SCI-EXPANDED(收录号:WOS:001730025000001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This study was supported by the Postgraduate Research & Practice Innovation Program of Jiangsu Province (Grant No. SJCX25_2399), the Gansu Provincial Health Commission Research Project (Grant Nos. GSWSKY2024-14 and GSWSKY2024-49), and the Science and Technology Department of Lanzhou City (Grant No. 2022-5-85).

语种：英文

外文关键词：congenital heart defects; lead; maternal blood; pregnancy; vanadium

摘要：Background: Using data from the Lanzhou Birth Cohort in China, this study examined the associations between prenatal exposure to vanadium (V) and lead (Pb)-both individually and jointly-and the risk of neonatal congenital heart defects (CHDs). Methods: This birth cohort study, conducted in Lanzhou, China, included 97 mother-newborn pairs assigned to the case group and 194 pairs serving as controls (1:2 ratio). Maternal blood concentrations of V and Pb were quantified using inductively coupled plasma mass spectrometry. Multivariate logistic regression was used to assess associations between prenatal V and Pb exposure levels and the risk of neonatal CHDs and specific subtypes. Interaction effects were further assessed using both additive and multiplicative models. Results: Maternal blood V concentrations were positively correlated with Pb levels. Higher maternal blood V levels were significantly associated with an increased risk of CHDs in offspring (p = 0.005), including isolated CHDs (p = 0.025), multiple CHDs (p = 0.013), patent ductus arteriosus (PDA, p = 0.025), and atrial septal defects (ASDs, p = 0.003). Similarly, elevated maternal blood Pb levels were linked to a higher risk of CHDs (p < 0.001), encompassing isolated CHDs (p = 0.002), multiple CHDs (p = 0.002), PDA (p < 0.001), ASDs (p = 0.048), and ventricular septal defects (VSDs, p = 0.015). Combined prenatal exposure to elevated V and Pb levels demonstrated a significant association with CHDs risk (p < 0.001). Conclusions: Maternal whole blood levels of V and Pb in late pregnancy, whether considered individually or jointly, were significantly associated with an increased risk of CHDs in the offspring.