文献类型：期刊文献

英文题名：Efficacy and safety of pharmacological intervention for smoking cessation in smokers with diseases: A systematic review and network meta-analysis

作者：Xing, Xin[1,2,3];Shang, Xue[4];Deng, Xinxin[1,2,5];Guo, Kangle[6];E, Fenfen[1,2,5];Zhou, Liying[1,2,5];Wang, Yongsheng[1,2,5];Yang, Chaoqun[1,2,5];Yang, Kehu[1,2];Li, Xiuxia[5]

第一作者：Xing, Xin;邢新

通信作者：Yang, KH[1];Li, XX[2]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China;[2]Key Lab Evidence Based Med & Knowledge Translat Ga, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China;[4]Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China;[5]Lanzhou Univ, Hlth Technol Assessment Ctr, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, Lanzhou, Peoples R China;[6]Gansu Prov Hosp, Dept Infect management, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou Univ, Hlth Technol Assessment Ctr, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, Lanzhou, Peoples R China.

年份：2023

卷号：16

期号：4

起止页码：520

外文期刊名：JOURNAL OF EVIDENCE BASED MEDICINE

收录：;Scopus(收录号：2-s2.0-85179662361);WOS:【SCI-EXPANDED(收录号:WOS:001125222400001)】；

基金：No Statement Available

语种：英文

外文关键词：network meta-analysis; pharmacotherapy; smoking cessation; systematic review

摘要：ObjectiveTo investigate the most effective and best-tolerated drugs for treating diseased smokers.MethodsEight databases were searched for randomized controlled trials (RCTs) involving different pharmacological interventions for smoking cessation in disease patients (January 2023). Network meta-analysis was performed using STATA 15.1 software. The Cochrane Risk of Bias Tool assessed the risk of bias, and confidence in evidence was assessed using CINeMA.ResultsA total of 60 RCTs involving 13,009 patients of 12 disease categories were included. All trials reported 13 interventions, resulting in 78 comparisons. Network meta-analysis showed that varenicline (OR = 2.30, 95% CI (1.77, 3.00)) and bupropion (OR = 1.65, 95% CI (1.29, 2.11)) showed favorable abstinence effects compared to placebo in the cardiovascular disease population. Nicotine replacement therapy (NRT) had better withdrawal advantages than placebo (OR = 11.18, 95% CI (2.25, 55.54)) in the chronic obstructive pulmonary disease (COPD) population. Some combination treatments showed better results than monotherapy, such as bupropion + NRT was superior to bupropion (OR = 8.45, 95% CI (1.84, 38.89)) and NRT (OR = 4.98, 95% CI (1.25, 19.78)) in mental illness population. The final surface under the cumulative ranking curve indicated that bupropion + NRT achieved the best smoking cessation effect. Overall confidence in the evidence was low. In a comparison of drugs, the results showed that bupropion + NRT had the best safety.ConclusionsMost interventions show the benefit of quitting smoking compared with placebo, including monotherapy and combination therapy. Moreover, varenicline or bupropion combined with NRT is superior to some monotherapies.