文献类型：期刊文献

英文题名：Impression life with pulmonary hypertension: clinically relevant characteristics and quality of life among patients in Gansu, China

作者：Zhang, Juxia[1];Wen, Yujie[2];Yin, Yuhuan[3];Zhang, Yiyin[3];Zhang, Rong[3];Zhang, Xiaoli[3];Ye, Jianying[3];Feng, Yuping[3];Meng, Hongyan[3]

第一作者：Zhang, Juxia

通信作者：Zhang, JX[1]

机构：[1]Gansu Prov Hosp, Clin Educ Dept, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Cardiovasc Dept, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Hosp, Clin Educ Dept, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Clin Educ Dept, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

卷号：18

外文期刊名：THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE

收录：;Scopus(收录号：2-s2.0-85191419963);WOS:【SCI-EXPANDED(收录号:WOS:001208855900001)】；

基金：The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the China Medical Education Association Project (2022KTZ010), the Natural Science Foundation of Gansu Province (21JR7RA607 and 21JR7RA613), the Scientific Research Foundation of Gansu Provincial Hospital (22GSSYD-69 and 22GSSYD-70)

语种：英文

外文关键词：HRQoL; MCS; 6MWD; PAH; PCS; WHO-FC

摘要：Background: The adverse effects of pulmonary arterial hypertension (PAH) on physical, emotional, and health-related quality of life (HRQoL) remain primarily unrecognized, especially in resource-limited settings. Objectives: This study aims to characterize the HRQoL of patients with PAH in this area and also identify the potential role of clinically relevant characteristics, including the 6-min walk distance test (6MWD), WHO-Functional Classification (WHO-FC), and mental health in the occurrence of lowering quality of life. Design: This was a cross-sectional observational study. Methods: Inpatients with PAH were chosen from a tertiary hospital located in Gansu province, China. All participants were interviewed face-by-face by using questionnaires, including items from the 36-Item Short Form Health Survey (SF-36), the self-rating anxiety scale, and the self-rating depression scale. Data on demographic and clinically relevant characteristics, including WHO-FC and 6MWD, were also collected by tracing medical recorders. Multiple linear regression analysis was used to determine the association between demographic, clinically relevant characteristics data, and physical component summary (PCS) or mental component summary (MCS) in SF-36. Results: Of the 152 participants, SF-36 differed significantly from Chinese norms in all eight domains, with role-physical (21.55 +/- 9.87) less than one-third of the norm (88.79 +/- 28.49). Multiple linear regression results showed that the factors with the greatest impact on PCS were anxiety scores (beta = -0.22, p = 0.001), followed by WHO-FC (beta = -0.16, p = 0.014) and 6MWD (beta = 0.15, p = 0.036). The factors with the greatest impact on MCS were WHO-FC (beta = -0.30, p < 0.001), followed by anxiety (beta = -0.23, p = 0.001) and depression scores (beta = -0.16, p = 0.013). Conclusion: HRQoL was substantially reduced among PAH patients in the resource-limited area, mainly the physiological functions. WHO-FC and anxiety scores were independently associated with both PCS and MCS in SF-36. Clinicians should make reasonable rehabilitation programs and plans for patients according to their cardiac function grade and the severity of clinical symptoms. In addition, psychological interventions should also be taken, especially for those with anxiety symptoms, so as to improve their HRQoL.