文献类型：期刊文献

英文题名：Acupoint injection treatment for primary osteoporosis: a systematic review and meta-analysis of randomized controlled trials

作者：Huang, Rui[1,2,3];Li, Xiuxia[2,3];Xu, Shihong[4,5];Li, Dingpeng[4,5];Yan, Peijing[6];Liu, Bo[1];Xie, Xingwen[4,5];Yang, Kehu[2,3,6,7]

第一作者：Huang, Rui

通信作者：Xie, XW[1];Yang, KH[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Sch Publ Hlth, Evidence Based Social Sci Res Ctr, Lanzhou 730000, Gansu, Peoples R China;[3]Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Inst Tradit Chinese Med, Lanzhou 730050, Gansu, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med, Dept Bone Oncol, Lanzhou 730050, Gansu, Peoples R China;[6]Gansu Prov Peoples Hosp, Inst Clin Res & Evidence Based Med, Lanzhou 730000, Gansu, Peoples R China;[7]Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Inst Tradit Chinese Med, Lanzhou 730050, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：8

期号：5

起止页码：586

外文期刊名：ANNALS OF PALLIATIVE MEDICINE

收录：;Scopus(收录号：2-s2.0-85075873264);WOS:【SCI-EXPANDED(收录号:WOS:000500465100008)】；

基金：This study was funded by the National Natural Science Foundation of China, China Program (No. 81860864), and it was funded by Laboratory of Intelligent Medical Engineering of Gansu Province (Grant no. GSXZYZH2018001), and it was also funded by the Special Scientific Research Project for Business Construction of Clinical Research Base of Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine (JDZX2015080).

语种：英文

外文关键词：Acupuncture; osteoporosis; meta-analysis; systematic review

摘要：Background: Acupoint injection has currently received increasing attention as a treatment for primary osteoporosis (POP), This study aimed to evaluate the efficacy and safety of acupoint injection as a clinical treatment for POP. Methods: Randomized controlled trials (RCTs) of acupoint injection compared with conventional non-acupoint injection for POP were identified in searches of seven databases from their inception to March 2019. All data were assessed and extracted by two authors independently. The risk of bias assessment recommended by the Cochrane Collaboration was used to assess the quality of the selected studies. RevMan 5.3 was used to conduct meta-analysis for the efficacy and safety of acupoint injection. Results: Five trials with 337 patients (aged 45-86 years) with bone mineral density (BMD) <= 2 SD were included in our meta-analysis. The results showed that, compared with conventional intramuscular injection, acupoint injection significantly increased the BM1) [mean difference (MD) =0.02; 95% CI, 0.01 to 0.03, P<0.05]. Subgroup analysis indicated that acupoint injection significantly improved lumbar BMD (MD =0.02; 95% CI, 0.01 to 0.03, P<0.05) but did not reduce the pain score (SMD =-2.29, 95% CI, -6.81 to 2.23, P>0.05). Individuals results showed that acupoint injection improved biochemical indicators, such as NBAP, IGF-I and reduced CTX and leptin levels. While the risk of bias was high in all five trials. Conclusions: This meta-analysis and systematic review suggests that acupoint injection improves BMD and some biochemical indicators in POP patients compared with the effects of conventional intramuscular injection. I Iowever, due to the high risk of bias in all the trials reviewed, the evidence remains inconclusive and future research will be required with improved methodological quality.