文献类型：期刊文献

英文题名：Novel Fluorescent Nanobiosensors for Rapid and Sensitive Detection of Organophosphorus Pesticide Residues in Angelica sinensis: A Performance Evaluation Against LC-MS

作者：Mu, Xiqiong[1,2,3];Dong, Yaqin[1,2,3];Jin, Ling[1,2,3,4];Zhu, Tiantian[1,2,3]

第一作者：Mu, Xiqiong

通信作者：Jin, L[1];Zhu, TT[1];Jin, L[2];Zhu, TT[2];Jin, L[3];Zhu, TT[3];Jin, L[4]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Minist Educ & Prov Coconstruct Collaborat Innovat, Lanzhou 730000, Peoples R China;[3]Gansu Prov Engn Res Ctr Evaluat Protect & Utilizat, Lanzhou 730000, Peoples R China;[4]Long Med Mat Ind Innovat Res Inst, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Minist Educ & Prov Coconstruct Collaborat Innovat, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Prov Engn Res Ctr Evaluat Protect & Utilizat, Lanzhou 730000, Peoples R China;[4]corresponding author), Long Med Mat Ind Innovat Res Inst, Lanzhou 730000, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2026

卷号：16

期号：6

外文期刊名：BIOSENSORS-BASEL

收录：;EI(收录号：20262621005514);Scopus(收录号：2-s2.0-105043134207);WOS:【SCI-EXPANDED(收录号:WOS:001804071900001)】；

基金：This work was supported by the Major Project of Gansu Provincial Joint Research Fund (No. 25JRRA1171), the Major Science and Technology Project of Gansu Province (No. 23ZDFA0131), the Open Fund of Key Laboratory of Traditional Chinese Medicine Quality and Standardization of Gansu Province (No. ZYZL2025-03), the Young Doctoral Talent "Enterprise and Park Integration" Program of Gansu Provincial Universities in 2026 (No. 2026QB-066), and the Scientific Research Start-up Fund for Introduced Talents, Gansu University of Chinese Medicine, 2024 (No. 2025YJRC-10).

语种：英文

外文关键词：organophosphorus pesticide residues; fluorescent nanosensor; liquid chromatography-mass spectrometry; Angelica sinensis

摘要：This study compares the performance of novel fluorescent nanobiosensors and liquid chromatography-mass spectrometry (LC-MS) for detecting organophosphorus pesticide residues in Angelica sinensis. Key parameters such as recovery rate and relative standard deviation (RSD) were evaluated to identify a preferable detection method. The results show that the fluorescent nanobiosensor offers superior sensitivity, whereas LC-MS excels in accuracy and quantitative analysis. For phoxim, the GQDs@GSH sensor achieved an LOD of 0.075 mu mol & centerdot;L-1, with recoveries of 97.65-100.62% (RSD < 3.35%). For glyphosate, the PDOA/Cu2+ sensor achieved an LOD of 1.8 nmol & centerdot;L-1, and the AgNCs sensor achieved an LOD of 21 nmol & centerdot;L-1, with recoveries of 91.30-105.34% (RSD < 3.35%). The originality of this work is threefold and does not claim de novo synthesis of unknown materials: (i) it is the first validation of three existing fluorescent nanosensors (GQDs@GSH, PDOA/Cu2+, and AgNCs) specifically for organophosphorus pesticide detection in the complex medicinal plant matrix Angelica sinensis; (ii) it provides the first systematic comparison of these nanosensors against the pharmacopeia-standard LC-MS method in this matrix, delineating their complementary advantages; (iii) it is the first assessment of their phytotoxicity in Angelica sinensis seedlings, demonstrating biocompatibility and potential for in planta imaging.