文献类型：期刊文献

中文题名：当归治疗围绝经期综合征的现代临床应用及量效规律

英文题名：Modern Clinical Application and Dose-Effect Law of Angelica Sinensis in Treatment of Perimenopausal Syndrome

作者：胡诗宛[1];卫若楠[2];张湘苑[1];沈梦菲[1];张琪棋[3];周凌[1];赵林华[3];张伟[2,3]

第一作者：胡诗宛

机构：[1]北京中医药大学,北京100029;[2]甘肃中医药大学,甘肃兰州730000;[3]中国中医科学院广安门医院,北京100053

第一机构：北京中医药大学,北京100029

年份：2022

卷号：50

期号：12

起止页码：47

中文期刊名：中医药学报

外文期刊名：Acta Chinese Medicine and Pharmacology

收录：CSTPCD

基金：中国中医科学院科技创新工程项目资助(CI2021A01605);国家重点基础研究发展计划(973计划)(2010CB530601)。

语种：中文

中文关键词：围绝经期综合征;当归;关联规则;用药规律;量效关系

外文关键词：Perimenopausal syndrome;Angelicae sinensis;Association rules;Medication law;Dose-effect relationship

摘要：目的:基于数据挖掘技术,探究当归在现代临床治疗围绝经期综合征(PMPS)中的临床用药规律和特点。方法:检索从建库至2020年12月31日期间发表在CNKI、WanFang database、VIP database、CBM中运用含当归的方剂治疗PMPS的文献,采用频数统计、关联规则等数据挖掘方法进行分析。结果:筛选出含当归汤剂的文献461篇,其中针对PMPS特定证候治疗的有95篇,针对PMPS主症治疗的有79篇;挖掘当归常用剂量范围为5~30 g,最常用的剂量为10 g,平均值为12.44 g;归纳以“肝肾阴虚证”“肝郁气滞证”为首的8种常见中医证候,以“柴胡”“白芍”为首的40味高频配伍中药;发现当归治疗PMPS的“量-症”高频规律(如:前项→后项):当归15 g→潮热汗出、当归12 g→关节与肌肉不适、当归12 g→睡眠障碍、当归12 g→潮热汗出、当归9 g→心情抑郁,此外,阴道干涩→当归15 g、性生活质量下降→当归12 g的关联提升度大于2,提示可能有实际强关联;找到“量-效”规律:当归是否作为主药(主药为方中剂量最大的药味)情况下,当归剂量有统计学差异(P<0.01),而方剂药味数差异无统计学意义(P>0.05)。结论:当归治疗围绝经期综合征的现代临床应用广泛,当归在不同剂量下可用于治疗围绝经期综合征的不同症状,具有一定“量-效”规律。
Objective:To explore the law and characteristics of clinical use of Angelicae Sinensis in the modern clinical treatment of perimenopausal syndrome(PMPS)based on data mining.Methods:Literature on treatment of PMPS with Angelicae Sinensis-containing prescriptions,were retrieved from CNKI,WanFang Database,VIP,and CBM from the time that these databases were established to December 31,2020,and using frequency statistics and association rules to analyze the data.Results:A total of 461 literature containing Angelicae Sinensis were screened out,among which 95 literature were for PMPS and 79 for major symptoms of PMPS;the clinical dose range of Angelicae Sinensis was 5~30 g,the most commonly used dose was 10 g,and the average dose was 12.44 g;there were 8 kinds of common TCM syndromes led by Yin deficiency of Liver and Kidney and Liver-Qi stagnation,and 40 high-frequency compatible Chinese medicinal led by Bupleuri and White peony;it was found the high-frequency law of dose-syndrome of Angelicae Sinensis in treatment of PMPS(for example:the former→the latter),i.e.15 g Angelicae Sinensis→hot flashes and night sweat,12 g Angelicae Sinensis→joint and muscle discomfort,12 g Angelicae Sinensis→sleep disorder,12 g Angelicae Sinensis→hot flashes and night sweat,9 g Angelicae Sinensis→depression;besides,the lift of vaginal dryness→15 g Angelicae Sinensis and decline in sexual quality of life→12 g Angelicae Sinensis were higher than 2 in terms of degree of correlation enhancement,which meant these two laws could have great relevance in reality;finding the‘dose-effect’law whether Angelicae Sinensis was the main medicinal(the largest dose in one prescription),there was a significant difference in the dose of Angelicae Sinensis(P<0.01),but there was no significant difference in the amounts of medicinal(P>0.05).Conclusion:Angelicae Sinensis has been widely used in treatment of PMPS in modern clinical practice.It can be used to treat different symptoms in different doses following a certain‘dose-effect’law.