文献类型：期刊文献

中文题名：组学技术在半夏质量评价与药理作用机制研究中的应用

英文题名：Application of omics in quality evaluation and pharmacological mechanism of Pinellia ternata

作者：刘源[1,2];徐圆圆[1,2];齐玉娟[1,2];孙逊[1,2];权文越[1,2];贾袭伟[3];曾翠云[1,2];王惠珍[1,2];高素芳[1,2];郭大权[4];郭威成[4];张兴俊[5];陈红刚[1,2];杜弢[1,2]

第一作者：刘源

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]陇药产业创新研究院,甘肃兰州730000;[3]宁夏职业技术学院生命科技学院,宁夏银川750021;[4]陇南民乐种业科技有限公司,甘肃西和742100;[5]甘谷县农业产业服务中心,甘肃天水741200

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2026

卷号：51

期号：7

起止页码：1843

中文期刊名：中国中药杂志

外文期刊名：China Journal of Chinese Materia Medica

收录：;北大核心:【北大核心2023】；

基金：国家中药材产业技术体系建设专项(CARS-21);甘肃省科技计划项目(21YF5NA130,22CX8NA069);宁夏自然科学基金项目(2024AAC03354)。

语种：中文

中文关键词：组学技术;半夏;质量评价;药理作用机制

外文关键词：omics technology;Pinellia ternata;quality evaluation;pharmacological mechanism

摘要：组学技术作为系统生物学的重要组成部分,以其高通量、整体性的分析优势,正在深刻变革中药的研究模式。半夏Pinellia ternata作为具有燥湿化痰、降逆止呕、消痞散结功效的常用中药,其质量控制和复杂药理机制的阐释是研究的重点与难点。该文系统综述了基因组学、转录组学、蛋白质组学、代谢组学等组学技术在半夏质量评价(涵盖栽培环境、种质资源、炮制加工等因素)和药理作用机制(包括止呕、化痰平喘、治疗胃肠道疾病、抗肿瘤等)研究中的应用进展。通过梳理现有研究成果,总结了组学技术在揭示半夏药效物质基础、品质形成机制及多靶点作用网络方面的巨大潜力,并展望了多组学整合、数据挖掘与人工智能等未来研究方向,以期为半夏的现代化、国际化研究提供系统的理论参考和方法学借鉴。
As an important component of systems biology,omics technologies,with their advantages of high-throughput and holistic analysis,are profoundly transforming the research model of TCM.Pinellia ternata,a commonly used TCM with the effects of drying dampness and resolving phlegm,directing rebellious Qi downward to stop vomiting,and relieving stuffiness and dissipating binds,presents major challenges in quality control and in the elucidation of its complex pharmacological mechanisms.This article systematically reviews the application progress of omics technologies such as genomics,transcriptomics,proteomics,and metabolomics in the study of P.ternata's quality evaluation(covering factors such as cultivation environment,germplasm resources,and processing)and pharmacological mechanisms(including antiemetic effects,phlegm resolution and asthma relief,treatment of gastrointestinal diseases,and antitumor activities).By sorting through existing research findings,it summarizes the great potential of omics technologies in revealing the pharmacodynamic material basis,quality formation mechanisms,and multi-target action networks of P.ternata,and further looks ahead to future research directions such as multi-omics integration,data mining,and artificial intelligence,with a view to providing systematic theoretical and methodological references for the modernization and internationalization of P.ternata research.