文献类型：期刊文献

英文题名：Association between antibiotic use and the risk of rheumatoid arthritis A protocol for a systematic review

作者：Meng, Tingting[1];Zhang, Shibin[1];Wang, Dawei[2];Zhang, Haijun[3];Song, Zhongyang[4];Li, Shengdong[5];Chen, Min[1,6];Tang, Chunzhi[7]

第一作者：Meng, Tingting

通信作者：Chen, M[1];Tang, CZ[2]

机构：[1]Macau Univ Sci & Technol, Fac Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China;[2]Guangzhou Univ Chinese Med, Shunde Dist Hosp Chinese Med Foshan City, Shunde Hosp, Foshan, Guangdong, Peoples R China;[3]Gansu Univ Chinese Med, Gansu Prov Peoples Hosp 2, Dept Orthopaed, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Clin Med Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[5]Second Hosp Yinzhou, Dept Rheumatol, Ninbo Zhejiang, Peoples R China;[6]Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China;[7]Guangzhou Univ Chinese Med, Clin Med Coll Acupuncture Moxibust & Rehabil, Guangzhou, Guangdong, Peoples R China

第一机构：Macau Univ Sci & Technol, Fac Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China

通信机构：[1]corresponding author), Ave Wai Long, Taipa 999078, Macau, Peoples R China;[2]corresponding author), 232 East Outer Ring Rd, Guangzhou 510000, Guangdong, Peoples R China.

年份：2020

卷号：99

期号：9

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85080033145);WOS:【SCI-EXPANDED(收录号:WOS:000525865600017)】；

基金：This work was funded by the Science and Technology Development Fund, Macau SAR (grant no.: 0010/2019/A Min Chen) and Guangdong Natural Science Foundation (grant no: 2015A030313368 Dawei Wang).

语种：英文

外文关键词：antibiotic; meta-analysis; protocol; rheumatoid arthritis; systematic

摘要：Background: The potential association between antibiotic use and the risk of rheumatoid arthritis (RA) has drawn significant attention from clinicians and researchers in recent years due to the wild usage of antibiotic. This study aimed to perform a systematic review and meta-analysis of the literature to determine if antibiotic use is associated with an increased risk of RA, so as to provide an important reference for clinical decision-making. Methods: Case-control and nest case-control studies of assessing whether antibiotic use is associated with the onset of RA will be identified in searches of 4 databases from their inception to August 2019. All data were assessed and extracted by 2 authors independently. The Newcastle-Ottawa scale was used to assess the quality of the selected studies. Manager Software 5.3 from Cochrane Collaboration (London, UK) and Stata 15.1 (Stata Corp, College Station, TX) will be used to conduct meta-analysis, determining pooled odds ratios and evaluating heterogeneity between studies. Result: The results of this systemic review and meta-analysis will be submitted to a recognized journal for publication. Conclusion: This systemic review and meta-analysis will determine if antibiotic use is associated with an increased risk of RA. We hope this study can make a definitive conclusion for the association.