文献类型：期刊文献

英文题名：Microbial metabolites in tumor metabolic reprogramming and immunotherapy: new insights

作者：Wang, Yi[1];Huang, Dan[1];Wang, Rongrong[1];Yin, Jiaojiao[2];Pei, Jianying[2];Zhang, Chong[2]

第一作者：王英;王宇;王艳;王昱;王琰;王莹;王越;王勇;王媛;王燕;王云;王悦

通信作者：Pei, JY[1];Zhang, C[1]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Matern & Child Care Hosp, Dept Clin Lab Ctr, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Prov Matern & Child Care Hosp, Dept Clin Lab Ctr, Lanzhou, Gansu, Peoples R China.

年份：2025

卷号：15

外文期刊名：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-105022645262);WOS:【SCI-EXPANDED(收录号:WOS:001618856600001)】；

基金：The author(s) declare financial support was received for the research and/or publication of this article. This work was supported by grants from the Natural Science Foundation of Gansu Province (24JRRA937), the Excellent Introduced Talents and Doctoral Startup Fund Project of Gansu Provincial Maternity and Child Care Hospital (GMCCH2024 - 2 - 7), and the Major Project of Scientific and Technological Innovation in Gansu Provincial Health Industry (GSWSQNPY2025 - 12), the Talent Training Project of Gansu Provincial Maternity and Child Care Hospital (GM CCH2025-2-3-04).

语种：英文

外文关键词：gut microbiota; microbial metabolites; tumor metabolic reprogramming; immune cell reprogramming; cancer immunotherapy; clinical translation

摘要：Gut microbiota and intratumoral microbiota have been recognized as critical regulators of tumor initiation and progression, with their metabolites exerting multifaceted effects on cancer development. This review systematically summarizes the roles and mechanistic classifications of microbial metabolites in tumor metabolic reprogramming, highlighting three principal regulatory layers: direct modulation of metabolic enzyme activity, regulation via signaling pathways, and immunometabolic modulation. Furthermore, it discusses the potential of microbial metabolites in regulating immune cell metabolism and enhancing immunotherapeutic efficacy, alongside summarizing the progress of relevant clinical studies. Finally, the review emphasizes that despite significant advances, current research still faces multiple challenges. Future investigations integrating cutting-edge technologies are essential to accelerate the translation of fundamental findings into clinical applications and to promote the development of metabolite-centered precision therapeutic strategies.