文献类型：期刊文献

中文题名：甲醛致运动大鼠骨骼肌氧化损伤及刺五加的作用研究

英文题名：Protective Effects of Oxidative Damage Induced by Formaldehyde in Rat Skeletal Muscle Motion and Acanthopanax

作者：贾文娟[1];陈静[1]

第一作者：贾文娟

机构：[1]定西师范高等专科学校体育系

第一机构：甘肃中医药大学定西校区

年份：2014

卷号：35

期号：5

起止页码：71

中文期刊名：体育科技

外文期刊名：Sport Science and Technology

收录：国家哲学社会科学学术期刊数据库

语种：中文

中文关键词：甲醛;刺五加;氧化性损伤;谷胱甘肽过氧化物酶;超氧化物歧化酶;过氧化氢酶;丙二醛;骨骼肌

外文关键词：formaldehyde; acanthopanax senticosus; oxidative damage; glutathione peroxidase; superoxide dismutase; catalase;malondialdehyde; skeletal muscle

摘要：目的:探讨甲醛染毒对运动大鼠骨骼肌的毒性及刺五加的保护作用。方法:采用40只2月龄雄性Wistar大鼠,体重(180士10)g,随机分为对照组、模型组、刺五加组进行动式染毒,甲醛剂量分别为0.8mg/m3,2.4mg/m3。每天染毒30min,每周6次,连续4周,刺五加的灌胃剂量为104.17mg/kg,测定运动大鼠骨骼肌组织中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH—Px)、过氧化氢酶(CAT)的活性和丙二醛(MDA)的含量。结果:模型组与对照组相比,模型组大鼠骨骼肌组织中CAT、GSH-PX、SOD活性均明显低于对照组(P[Objective]： To investigate the protective effect of the toxicity of formaldehyde exposure in rat skeletal muscle motion and Acanthopanax.[ Methods]： 40 2-month-old male Wistar rats weighing （180 - 10） g, were randomly divided into control group, model group, Acanthopanax group acting exposure, formaldehyde doses were 0.8mg/m^3, 2.4 mg/m^3. Exposed daily 30rain, 6 times a week for 4 weeks, the dose administered Acanthopanax for 104.17mg/kg, measured movement rat skeletal muscle superoxide dismutase （SOD）, glutathione peroxide matter enzymes （GSH-Px）, catalase （CAT） and malondialdehyde vitality （MDA） content. [Results]： The model group compared with the control group, the skeletal muscle of high-dose model group CAT, GSH-PX, SOD activity was significantly lower than the control group （P 〈O.01）, MDA content was significantly higher （P 〈O.01）. Acanthopanax group compared with the model group, low-dose rat skeletal muscle Acanthopanax group CAT, GSH-PX, SOD activity was significantly higher than the exposure exercise group （P 〈O.01）, MDA content was significantly lower than the exposure exercise group （P 〈O.01） [Conclusion]： Formaldehyde can cause skeletal muscle movement oxidative damage in rats, and fed Acanthopanax medicine can effectively alleviate their toxicity.