文献类型：期刊文献

中文题名：中药调节肠道菌群缓解药物性肝损伤的研究进展

英文题名：Research progress on traditional Chinese herbal medicines modulating gut microbiota to alleviate drug?induced liver injury

作者：杨必乾[1,2];何慧明[1];殷亭湄[2];付晓艳[2];高广淼[2];杨玲玲[2];李洁[2];邓毅[2,3]

第一作者：杨必乾

机构：[1]广元市中医医院,四川广元628000;[2]甘肃中医药大学,甘肃兰州730000;[3]甘肃省中药药理与毒理学重点实验室,甘肃兰州730000

第一机构：广元市中医医院,四川广元628000

年份：2024

卷号：58

期号：3

起止页码：92

中文期刊名：上海中医药杂志

外文期刊名：Shanghai Journal of Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：国家自然科学基金项目(81960723);甘肃省科技计划项目(21JR11RA145);甘肃省优秀博士生项目(22JR5RA577);甘肃省中药炮制技术传承基地项目(2022)。

语种：中文

中文关键词：药物性肝损伤;肠道菌群;中药复方;中药成分;作用机制

外文关键词：drug-induced liver injury;gut microbiota;traditional Chinese medicine compound formula;traditional Chinese medicine components;mechanism of action

摘要：药物性肝损伤是由化学药物、膳食补充剂和草药产品等引起的肝脏损伤疾病,其极易发展为肝衰竭,且在其发生发展的同时常伴随肠道菌群的变化。中药多成分、多靶点的治疗特点可以通过调节肠道菌群、改善肠道屏障、降低炎症因子水平等减轻药物性肝损伤。对中药干预肠道菌群缓解药物性肝损伤的作用进行总结,以期对中药治疗药物性肝损伤的机制研究提供参考。
Drug-induced liver injury(DILI)is a hepatic disorder caused by chemical drugs,dietary supplements,and herbal products,which can easily progress to liver failure.Its development and progression often coincide with changes in the gut microbiota.Traditional Chinese herbal medicines(TCHMs),with its multi-component and multi-target therapeutic characteristics,can mitigate DILI by modulating the gut microbiota,enhancing intestinal barrier,and reducing levels of inflammatory factors.This review summarizes the role of TCHMs in intervening with the gut microbiota to alleviate DILI,with the aim of providing references for further research into the mechanisms of TCHMs in treating DILI.