文献类型：期刊文献

英文题名：Mitochondrial dysfunction in hypertension: mechanistic pathways and therapeutic implications

作者：Tian, Jiao[1];Yi, Lin[1];Lu, Yuyuan[1];Kou, Yushun[1];Zhang, Lingna[1];Jin, Penghui[2];Wang, Xiaoke[2];Wu, Tao[1];Yang, Xin[2];Wang, Yiyuan[1];Ma, Ruiling[1]

第一作者：Tian, Jiao

通信作者：Yi, L[1]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：26

期号：1

外文期刊名：FUNCTIONAL & INTEGRATIVE GENOMICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001684258200002)】；

基金：The National Natural Science Foundation of China, No. 82160842; Traditional Chinese Medicine Scientific Research Project in Gansu Province in 2023, No. GZKP-2023-40; Open Subjects of Dunhuang Medicine in the Key Laboratory of Translation of the Ministry of Education, No. DHYX23-07; General Program of the Joint Scientific Research Fund, No. 23JRRA1521; The Department of Science and Technology of Gansu Province and the Natural Science Foundation of Gansu Province, No.24JRRA590; 2025 Gansu Provincial Innovation Fund Project for University Teachers, No.2025 A-111.

语种：英文

外文关键词：Hypertension; Mitochondria; Oxidative stress; Mitophagy; Uncoupling; Fusion and fission; Ca2+ handling; Chinese herb extracts; Western substances compounds

摘要：Hypertension is a major global cardiovascular disorder characterized by complex and multifactorial pathogenesis. Although numerous antihypertensive therapies are available, a considerable proportion of patients continue to exhibit inadequate blood pressure control. Emerging evidence underscores the central role of mitochondrial dysfunction in the development and progression of hypertension. As regulators of energy metabolism, redox balance, calcium signaling, and cell survival, mitochondria play a significant role in maintaining vascular and neuronal homeostasis. Mitochondrial abnormalities-such as excessive ROS production, impaired mitophagy, disrupted fusion and fission dynamics, and calcium dysregulation-can amplify vascular dysfunction and sympathetic overactivation, thereby elevating blood pressure. This review summarizes current advances in mitochondrial pathophysiology in hypertension and discusses mitochondrial-targeted therapeutic strategies. Natural products derived from traditional Chinese medicine (e.g., apigenin, berberine, curcumin) and Western compounds (e.g., MitoTEMPO, empagliflozin, Mdivi-1) show promise in mitigating mitochondrial stress and lowering blood pressure. A deeper understanding of mitochondria-centered mechanisms may offer novel opportunities for precision therapy, particularly in resistant hypertension.