详细信息
甘草活性成分对顺铂致肝肾损害防治作用研究进展 被引量:5
Prevention and Treatment of Cisplatin-Induced Liver and Kidney Damage by Active Components of Gancao(甘草):A Review
文献类型:期刊文献
中文题名:甘草活性成分对顺铂致肝肾损害防治作用研究进展
英文题名:Prevention and Treatment of Cisplatin-Induced Liver and Kidney Damage by Active Components of Gancao(甘草):A Review
作者:张楠[1];闫潇[1];连小龙[1];张尚龙[1];马趣环[1];叶礼巧[1];邓毅[1,2]
第一作者:张楠
机构:[1]甘肃中医药大学,兰州730000;[2]甘肃省中药药理与毒理学重点实验室,兰州730000
第一机构:甘肃中医药大学
年份:2023
卷号:39
期号:2
起止页码:125
中文期刊名:中药药理与临床
外文期刊名:Pharmacology and Clinics of Chinese Materia Medica
收录:北大核心:【北大核心2020】;CSCD:【CSCD2023_2024】;
基金:国家自然科学基金(地区)项目(编号:81960723);甘肃省中医药管理局(编号:GZKP-2022-37);甘肃省自然科学基金项目(编号:21JR11RA145);兰州市科技计划项目(编号:2022-3-21)。
语种:中文
中文关键词:甘草;活性成分;顺铂;肝肾损害;防治
外文关键词:Gancao(甘草);active components;cisplatin;liver and kidney damage;prevention and treatment
摘要:顺铂为临床常用的抗肿瘤药物,疗效显著但毒副作用较强。主要表现为肾毒性、肝毒性、耳毒性、心脏毒性、神经毒性及其他毒性等,且尤以肝肾损伤较为严重。甘草作为中药解毒的常用药,具有补脾益气,清热解毒之功。因此本文从化疗药物顺铂对肝肾产生损害的机制及甘草活性成分在防治顺铂引起肝肾损害方面的作用进行概述,旨在为临床甘草与顺铂联合应用增效减毒提供依据。
Cisplatin,an anti-tumor drug,demonstrates remarkable therapeutic effect but induces severe side effects.The main manifestations are nephrotoxicity,hepatotoxicity,ototoxicity,cardiotoxicity,and neurotoxicity,especially the damage to the liver and kidney.Gancao(草)a common detoxifying Chinese medicinal,has the functions of Bupi(补脾),Yiqi(益气),Qingre(清热)and Jiedu(解毒).Therefore,this paper summarized the mechanism underlying the damage of cisplatin to liver and kidney and the efects of active components in Gancao against the cisplatin-induced damage to liver and kidney,providing evidence for the synergy and toxicity reduction of Gancao in combination with cisplatin.
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