文献类型：期刊文献

中文题名：治萎防变胶囊对慢性萎缩性胃炎大鼠血清胃泌素和胃酸含量的影响

英文题名：Effects of Zhiwei Fangbian Capsule on Contents of Serum Gastrin and Gastric Acid in Rats with Chronic Atrophic Gastritis

作者：朱立鸣[1];段永强[1];成映霞[1];张虹[2];梁玉杰[1]

第一作者：朱立鸣

机构：[1]甘肃中医学院,甘肃兰州730020;[2]甘肃省第二人民医院,甘肃兰州730020

第一机构：甘肃中医药大学

年份：2009

卷号：15

期号：11

起止页码：834

中文期刊名：中国中医基础医学杂志

外文期刊名：JOURNAL OF BASIC CHINESE MEDICINE

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD_E2011_2012】；

基金：甘肃省中医管理局科技计划项目(07-GZK-07);甘肃中医学院中青年基金项目(05ZQ-03)

语种：中文

中文关键词：治萎防变胶囊;胃泌素;胃蛋白酶;胃液总酸;游离酸

外文关键词：Zhiweifangbian capsule（ZWFB）; gastrin; pepsinum; gastric juice; acidum; free acid

摘要：目的:研究治萎防变胶囊对慢性萎缩性胃炎模型大鼠血清胃泌素、胃蛋白酶活性、胃液总酸和游离酸含量的影响。方法:采用综合法复制CAG动物模型,施药后对各组大鼠相关指标进行检测。结果:与模型组比较,治萎防变胶囊可显著提高胃蛋白酶活性及升高血清胃泌素、胃液总酸含量和游离酸含量,大剂量组作用显著。结论:治萎防变胶囊具有促进血清胃泌素、胃酸分泌及提高胃蛋白酶活性的作用。
Objective To study effects of Zhiweifangbian capsule（ZWFB）on the level of gastfin in serum, activity of pepsinum in gastric tissue and content of acidum and free acid in gastric juice of rats with chronic atrophic gastritis. Methods Model of chronic atrophic gastritis was established with synthetic method. After treated with ZWFB, the serum level of gastrin, activity of pepsinum in gastric tissue and content of acidum and free acid in gastric juice were detected. Results Compared with model group, ZWFB could increase the serum level of gastrin, activity of pepsinum and content of acidum and free acid significantly. Conclusion It was suggested that ZWFB has functions of promoteing gastrin secretions, gastric acid secretion and promoteing pepsinum activity.