文献类型：期刊文献

英文题名：Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

作者：An, Fangyu[1];Meng, Xiangrui[2];Yuan, Lingqing[3];Niu, Yanqiang[2];Deng, Jie[2];Li, Zhaohui[2];Liu, Yongqi[3];Xia, Ruoliu[2];Liu, Shiqing[2];Yan, Chunlu[4]

第一作者：安方玉

通信作者：Liu, YQ[1];Yan, CL[2]

机构：[1]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：18

期号：1

外文期刊名：CELL DIVISION

收录：;Scopus(收录号：2-s2.0-85149983880);WOS:【SCI-EXPANDED(收录号:WOS:000943673400001)】；

语种：英文

外文关键词：Osteoporosis; NcRNA; Wnt; Bone metabolism; Network regulation

摘要：Non-coding RNA (ncRNA) is a type of non-protein-coding RNA molecule transcribed from the genome which performs broad regulation of a variety of biological functions in human cells. The Wnt signaling pathway is highly conserved in multicellular organisms, playing an important role in their growth and development. Increasing evidence suggests that ncRNA can regulate cell biological function, enhance bone metabolism, and maintain normal bone homeostasis by interacting with the Wnt pathway. Studies have also demonstrated that the association of ncRNA with the Wnt pathway may be a potential biomarker for the diagnosis, evaluation of prognosis, and treatment of osteoporosis. The interaction of ncRNA with Wnt also performs an important regulatory role in the occurrence and development of osteoporosis. Targeted therapy of the ncRNA/Wnt axis may ultimately be the preferred choice for the treatment of osteoporosis in the future. The current article reviews the mechanism of the ncRNA/Wnt axis in osteoporosis and reveals the relationship between ncRNA and Wnt, thereby exploring novel molecular targets for the treatment of osteoporosis and providing theoretical scientific guidance for its clinical treatment.