文献类型：期刊文献

英文题名：Curcumin blunts epithelial-mesenchymal transition to alleviate invasion and metastasis of prostate cancer through the JARID1D demethylation

作者：Xie, Qinghua[1,2];Hu, Yaohua[1];Zhang, Chenyang[1,3];Zhang, Caiqin[1];Qin, Jing[1];Zhao, Yong[1];An, Qingling[1];Zheng, Jie[4];Shi, Changhong[1]

第一作者：Xie, Qinghua

通信作者：Shi, CH[1]

机构：[1]Fourth Mil Med Univ, Lab Anim Ctr, Div Canc Biol, Xian 710032, Shaanxi, Peoples R China;[2]Guangzhou Univ Chinese Med, Anim Expt Ctr, Guangzhou 510405, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou 730030, Peoples R China;[4]Fourth Mil Med Univ, Natl Demonstrat Ctr Expt Preclin Med Educ, Xian 710032, Peoples R China

第一机构：Fourth Mil Med Univ, Lab Anim Ctr, Div Canc Biol, Xian 710032, Shaanxi, Peoples R China

通信机构：[1]corresponding author), Fourth Mil Med Univ, Lab Anim Ctr, Div Canc Biol, Xian 710032, Shaanxi, Peoples R China.

年份：2024

卷号：24

期号：1

外文期刊名：CANCER CELL INTERNATIONAL

收录：;Scopus(收录号：2-s2.0-85202819729);WOS:【SCI-EXPANDED(收录号:WOS:001302579700001)】；

基金：The work was supported by the National Natural Science Foundation of China (32070532 and 32270566) and Shaanxi Province Innovation Capability Support Plan (2022PT-38).

语种：英文

外文关键词：JARID1D; Metastasis; Curcumin; Demethylase; Prostate cancer

摘要：Prostate cancer (PCa) is one of the most common and prevalent cancers in men worldwide. The majority of PCa-related deaths result from metastasis rather than primary tumors. Several studies have focused on the relationship between male-specific genes encoded on the Y chromosome and PCa metastasis; however, the relationship between the male specific protein encoded on the Y chromosome and tumor suppression has not been fully clarified. Here, we report a male specific protein of this type, the histone H3 lysine 4 (H3K4) demethylase JARID1D, which has the ability to inhibit the gene expression program related to cell invasion, and can thus form a phenotype that inhibits the invasion of PCa cells. However, JARID1D exhibits low expression level in advanced PCa, and which is related to rapid invasion and metastasis in patients with PCa. Curcumin, as a multi-target drug, can enhance the expression and demethylation activity of JARID1D, affect the androgen receptor (AR) and epithelial-mesenchymal transition (EMT) signaling cascade, and inhibit the metastatic potential of castration resistant cancer (CRPC). These findings suggest that using curcumin to increase the expression and demethylation activity of JARID1D may be a feasible strategy to inhibit PCa metastasis by regulating EMT and AR.