文献类型：期刊文献

英文题名：Association between the number of retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer: a systematic review and meta-analysis

作者：Liu, Qianqian[1,2];Huang, Min[1,2];Yang, Jing[1,2];Jiang, Mengyuan[1,2];Zhao, Ziru[1,2];Zhao, Haitong[3];He, Tingting[1,2];Bai, Yuping[4];Zhang, Rui[1,2];Zhang, Min[2]

第一作者：Liu, Qianqian

通信作者：Zhang, M[1]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Sci Res Off, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[4]Hainan Prov Peoples Hosp, Dept Pathol, Haikou, Hainan, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Sci Res Off, Lanzhou 730000, Gansu, Peoples R China.

年份：2023

卷号：13

期号：12

外文期刊名：BMJ OPEN

收录：;Scopus(收录号：2-s2.0-85181178132);WOS:【SCI-EXPANDED(收录号:WOS:001134943800074)】；

基金：This study was supported by the National Natural Science Foundation of China (grant no. 81860059), and Basic Research Innovation Group Project of Gansu Province (no.22JR5RA709).

语种：英文

外文关键词：systematic review; gastrointestinal tumours; public health

摘要：Objective Clinical practice guidelines recommend retrieving at least 12 lymph nodes for correct staging in colorectal cancer. However, it is difficult to retrieve adequate lymph nodes because of various factors. We aimed to evaluate the association between the number of retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer.Design Systematic review and meta-analysis of primary studies.Data sources PubMed, Embase, Cochrane and Web of Science were searched from January 2016 to June 2023.Eligibility criteria for selecting studies Studies that evaluated the association between retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer were included.Data extraction and synthesis OR with 95% conference intervals was extracted and pooled.Results A total of 54 studies containing 2 05 821 patients were included in this meta-analysis. The results showed that fewer nodes were retrieved from elderly patients (OR=0.70, 95% CI (0.54 to 0.90), p=0.005), and from tumours located in the left colon than in the right colon (OR=0.43, 95% CI (0.33 to 0.56), p<0.001). More lymph nodes were obtained from females than males (OR=1.15, 95% CI (1.04 to 1.28), p=0.006), from the advanced T stage (T3+T4) than T1+T2 stage (OR=1.57, 95% CI (1.25 to 1.97), p<0.001) and from the N2 stage than N0 stage (OR=1.32, 95% CI (1.15 to 1.51), p<0.001). Body mass index, ethnicity, N1 stage, M stage, tumour differentiation and lymph-vascular invasion were not significantly associated with the lymph node yield.Conclusions The study results suggest that clinicians have an increased opportunity to retrieve sufficient lymph nodes for accurate pathological staging to guide treatment decisions in patients with colorectal cancer who are young, female, with tumours located in the right colon, advanced T stage and N2 stage.