详细信息
文献类型:期刊文献
中文题名:高原肺水肿易感基因多态性研究进展
英文题名:Advances in susceptible gene polymorphism in high altitude pulmonary edema
作者:罗晓红[1];郭文静[1,2]
第一作者:罗晓红
机构:[1]兰州军区总医院内分泌科,甘肃兰州730020;[2]甘肃中医药大学,甘肃兰州730000
第一机构:兰州军区总医院内分泌科,甘肃兰州730020
年份:2016
卷号:37
期号:1
起止页码:96
中文期刊名:解放军医学院学报
外文期刊名:Academic Journal of Chinese PLA Medical School
收录:CSTPCD
基金:全军医药卫生科研基金项目(CLZ14JB06)~~
语种:中文
中文关键词:高原肺水肿;基因多态性
外文关键词:high altitude pulmonary edema; gene polymorphism;
摘要:高原肺水肿是因高原缺氧而严重危及病患生命的急性高原病,多见于3 000 m以上的高海拔地区,以发病急、危害大、病死率高为主要特点。目前国内外资料显示,该病具有较明显的遗传易感倾向。本文主要从线粒体基因、内皮生长因子基因、肾素-血管紧张素-醛固酮系统基因等方面对高原肺水肿的易感基因多态性研究进展作一综述,为高原肺水肿的发病和防治研究提供一定的资料。
High altitude pulmonary edema(HAPE) is a serious idiopathic mountain sickness which occurs quickly when exposed to altitude exceeding 3 000 m above sea level, and it is considered to be a life-threatening disease. Existing research results indicate that HAPE shows obvious individual susceptible tendency. This article makes a review on susceptibility genes polymorphisms of high altitude pulmonary edema from many respects, including the mitochondrial genes, endothelial growth factor gene, renin- angiotensin-aldosterone system gene and so on, so as to provide helpful references to its pathogenesis and prevention.
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