文献类型：期刊文献

英文题名：Reversed-phase separations on cellulose tris(3,5-dimethyl phenylcarbamate) chiral stationary phase

作者：Hou, JG; Wang, YL; Li, CX; Han, XQ; Gao, JZ; Kang, JW

第一作者：Hou, J.G.

通信作者：Gao, JZ[1]

机构：[1]NW Normal Univ, Inst Chem, Lanzhou 730070, Peoples R China;[2]Gansu Chinese Med Coll, Dept Chinese Herbs, Lanzhou 730000, Peoples R China;[3]Guizhou Normal Univ, Dept Chem, Guiyang 550001, Peoples R China

第一机构：NW Normal Univ, Inst Chem, Lanzhou 730070, Peoples R China

通信机构：[1]corresponding author), NW Normal Univ, Inst Chem, Lanzhou 730070, Peoples R China.

年份：1999

卷号：50

期号：1-2

起止页码：89

外文期刊名：CHROMATOGRAPHIA

收录：;EI(收录号：20242616496294);Scopus(收录号：2-s2.0-0032837055);WOS:【SCI-EXPANDED(收录号:WOS:000081720200017)】；

语种：英文

外文关键词：column liquid chromatography; chiral stationary phase; optical resolution; racemic compounds

摘要：The chiral separation of eight racemic compounds has been investigated on a cellulose tris(3,5-dimethylphenylcarbamate) chiral column under reversed-phase conditions. The discrimination mechanism under reversed-phase conditions is discussed. Addition of acid to the mobile phase is necessary for resolution of acidic racemic compounds. The presence of ion-pair reagent in the mobile phase is a key factor in the resolution of basic racemic compounds. Retention of the racemates is also affected by addition of acid or salt. The anion in buffer not only interacts wit the racemate, but also with the polysaccharide derivative on the silica gel surface.