文献类型：期刊文献

英文题名：Adiposity and reproductive characteristics across the lifespan: a multi-ethnic population-based study in Northwest China

作者：Zhang, Binyan[1,2];Mi, Baibing[2];Li, Chao[2];Xu, Kun[2];Cai, Jiaxin[2];Kang, Yijun[2];Wang, Duolao[3];Pei, Leilei[2];Shi, Guoshuai[2];Liu, Yezhou[2];Zeng, Lingxia[2];Li, Qiang[2];Shen, Yuan[2];Zhao, Yaling[2];Xiao, Shengbin[2];Dai, Jianghong[4];Zhang, Yuhong[5];Zhao, Yi[5];Wang, Xinhua[6];Ma, Fuchang[7];Liu, Jingchun[2];Cao, Suixia[2];Huo, Yating[2];Yan, Hong[2,8,9];Dang, Shaonong[2]

第一作者：Zhang, Binyan

通信作者：Yan, H[1];Dang, SN[1];Yan, H[2];Yan, H[3]

机构：[1]Xian Med Univ, Sch Publ Hlth, Xian, Peoples R China;[2]Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, 76 Yanta West Rd, Xian, Shaanxi, Peoples R China;[3]Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Biostat Unit, Pembroke Pl, Liverpool, England;[4]Xinjiang Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Urumqi, Xinjiang, Peoples R China;[5]Ningxia Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Yinchuan, Ningxia, Peoples R China;[6]Gansu Univ Chinese Med, Sch Publ Hlth, Dept Environm & Occupat Med, Lanzhou, Gansu, Peoples R China;[7]Qinghai Ctr Dis Prevent & Control, Dept Chron & Noncommunicable Dis Control & Prevent, Xining, Qinghai, Peoples R China;[8]Nutr & Food Safety Engn Res Ctr Shaanxi Prov, Xian, Peoples R China;[9]Xi An Jiao Tong Univ, Minist Educ, Key Lab Environm & Gene Related Dis, Xian, Peoples R China

第一机构：Xian Med Univ, Sch Publ Hlth, Xian, Peoples R China

通信机构：[1]corresponding author), Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, 76 Yanta West Rd, Xian, Shaanxi, Peoples R China;[2]corresponding author), Nutr & Food Safety Engn Res Ctr Shaanxi Prov, Xian, Peoples R China;[3]corresponding author), Xi An Jiao Tong Univ, Minist Educ, Key Lab Environm & Gene Related Dis, Xian, Peoples R China.

年份：2026

卷号：23

期号：1

外文期刊名：REPRODUCTIVE HEALTH

收录：;WOS:【SSCI(收录号:WOS:001681219900002)，SCI-EXPANDED(收录号:WOS:001681219900002)】；

基金：This research is supported by National Key Research and Development Program of China [No. 2017YFC0907200, 2017YFC0907201, 2017YFC0907202, 2017YFC0907203, 2017YFC0907204 and 2017YFC0907205].

语种：英文

外文关键词：Body mass index; Reproductive characteristics; Chinese; Ethnic; Birth cohort

摘要：Background Reproductive characteristics significantly shape physiological adaptations, little is known about how they relate to adiposity in women of multi-ethnic regions undergoing a rapid increase in obesity burden. This study aims to address this gap by assessing how reproductive patterns correlate with adiposity and identifying potential moderating factors among Chinese adults.
Methods In 2018-2019, 107,679 participants from the Regional Ethnic Cohort Study in China were included in this cross-sectional analysis. Restricted cubic spline and generalized linear regression models were used to assess the association of reproductive characteristics such as age at menarche and menopause, number of children, menopause status, duration of post-menopause, and reproductive years, as well as reproductive pattern with adiposity using body mass index (BMI). Reproductive pattern was characterized using a Higher-Risk Reproductive Score (HRRS), which incorporates key landmarks such as early menarche (< 12 years), having >= 3 children, and later age at menopause (>= 51 years).
Results Females' mean BMI was 24.4 (standard deviation, SD 3.8) kg/m(2), with the median age at menarche and menopause of 15.0 (interquartile range, IQR 2.0) and 49.0 (IQR 5.0), median number of children and reproductive years of 2.0 (IQR 1.0) and 34.0 (IQR 6.0). Age at menarche was non-linearly associated with an average drop of 0.13 kg/m(2) in BMI, particularly in Uyghur ethnic and younger adults. Age at menopause and reproductive years was non-linearly related to higher BMI by 0.05 and 0.07 kg/m(2) per year delay. Adiposity exhibited an inverted U-shape with number of children. The duration of post-menopause correlated with a BMI reduction of 0.08 kg/m(2) on average. The HRRS was associated with an increase of 0.56 kg/m(2) in BMI. Conclusions Among Chinese women, earlier age at menarche and later age at menopause were associated with increased adiposity. Adiposity showed an inverted U-shaped relationship with number of children, and a higher-risk reproductive pattern was linked to increased adiposity.