文献类型：期刊文献

英文题名：Association between hepatitis B virus infection and risk of osteoporosis: a systematic review and meta-analysis A protocol for systematic review

作者：Xie, Xingwen[1,2];Huang, Rui[3,4,5];Li, Xiuxia[4,5];Li, Ning[3];Zhang, Haijun[1,2];Xu, Shihong[6];Li, Dingpeng[1];Xi, Shanshan[7];Yang, Kehu[4,5,8,9]

第一作者：Xie, Xingwen

通信作者：Xie, XW[1];Yang, KH[2]

机构：[1]Northwest Minzu Univ, Affiliated Hosp, Dept Orthopaed, Lanzhou, Gansu, Peoples R China;[2]Gansu Second Prov Peoples Hosp, Dept Orthopaed, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Clin Med Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[4]Lanzhou Univ, Sch Publ Hlth, Evidence Based Social Sci Res Ctr, Lanzhou, Gansu, Peoples R China;[5]Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Gansu, Peoples R China;[6]Gansu Prov Hosp Tradit Chinese Med, Dept Bone Oncol, Lanzhou, Gansu, Peoples R China;[7]Hengshui Hosp Tradit Chinese Med, Dept Endocrinol & Nephrol, Hengshui, Hebei, Peoples R China;[8]Gansu Prov Peoples Hosp, Inst Clin Res & Evidence Based Med, Lanzhou, Gansu, Peoples R China;[9]Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China

第一机构：Northwest Minzu Univ, Affiliated Hosp, Dept Orthopaed, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), 1 West Hezheng St, Lanzhou 730000, Peoples R China;[2]corresponding author), 222 South Tianshui Rode, Lanzhou 730000, Peoples R China.

年份：2020

卷号：99

期号：16

起止页码：E19719

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85086495891);WOS:【SCI-EXPANDED(收录号:WOS:000544714800043)】；

基金：This work was funded by the National Natural Science Foundation of China (grant no.: 81860864 Xingwen Xie) and the Laboratory of Intelligent Medical Engineering of Gansu Province (Grant no. GSXZYZH2018001 Kehu Yang).

语种：英文

外文关键词：hepatitis B; meta-analysis; osteoporosis; systematic review

摘要：Background: The potential association between hepatitis B virus (HBV) infection and development of osteoporosis has drawn significant attention from clinicians and researchers in recent years due to the increasing prevalence of HBV infection. This study aims to perform a systematic review and meta-analysis of the literature to show whether HBV infection is associated with an increased risk of osteoporosis. Methods: Case-control, cohort, and cross-sectional studies that report the incidence of osteoporosis, osteoporotic fracture, osteopenia, and bone mineral density level in populations with HBV infection will be selected. Four databases from their inception to October 2019 will be searched. All data were assessed and extracted by 2 authors independently. The Newcastle-Ottawa scale and (Agency for Healthcare Research and Quality) Agency for Healthcare Research and Quality checklist will be used to assess the quality of the selected studies. Stata 15.1 (Stata Corp, College Station, TX) will be used to conduct meta-analysis. Result: The results of this systemic review and meta-analysis will be submitted to a recognized journal for publication. Conclusion: This systemic review and meta-analysis will determine whether HBV infection is associated with an increased risk of osteoporosis. We hope this review can provide a reliable evidence. Registration: PROSPERO (registration number CRD42020140522).