文献类型：期刊文献

中文题名：多原发肺癌诊断与治疗的最新研究进展

英文题名：Recent Advances in the Diagnosis and Management of Multiple Primary Lung Cancer

作者：洪子强[1,2];金大成[2];白向豆[1,2];崔百强[1,2];苟云久[2]

第一作者：洪子强

机构：[1]甘肃中医药大学第一临床医学院,甘肃省兰州市730000;[2]甘肃省人民医院胸外科,甘肃省兰州市730000

第一机构：甘肃中医药大学临床医学院

年份：2022

卷号：25

期号：27

起止页码：3435

中文期刊名：中国全科医学

外文期刊名：Chinese General Practice

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；

基金：甘肃省人民医院国家级科研项目培育计划一般项目(19SYPYB-28);甘肃省科技计划项目(20JR10RA388)。

语种：中文

中文关键词：肺肿瘤;多原发肺癌;肿瘤转移;诊断,鉴别;肺外科手术;放射疗法;免疫检查点抑制剂;分子靶向治疗;综述

外文关键词：Lung neoplasms;Multiple primary lung cancer;Neoplasm metastasis;Diagnosis,differential;Pulmonary surgical procedures;Radiotherapy;Immune checkpoint inhibitors;Molecular targeted therapy;Review

摘要：随着CT和肺癌筛查的广泛应用,多原发肺癌(MPLC)(即同个患者中发生两个或两个以上的原发恶性肺癌)的检出率逐渐增加,但如何准确鉴别MPLC和肺内转移(IM)仍是一个难题。组织学特征在某些情况下可以很好地鉴别MPLC和IM,但常需要进行分子分析,如下一代测序技术(NGS)的应用有助于鉴别MPLC和IM。而对于MPLC的治疗,手术仍然是主要的治疗方式,对于不能手术的患者,放疗和局部消融发挥着重要作用。NGS和新疗法(如靶向药物和免疫检查点抑制剂)的出现为MPLC的诊疗提供了新的选择。本研究就近年来MPLC诊断和治疗的研究进展进行论述。
The wide application of lung CT scan and lung cancer screening significnatly improves the detection rate of multiple primary lung cancer(MPLC),namely,lung cancer patients have two or more primaries at the same time.It is a tough problem all the time that how to distinguish between MPLC and intrapulmonary metastases(IM).Although histological feature analysis is a good means to distinguish them in some circumstances,molecular analysis is also needed generally.Such as the application of next generation sequencing(NGS)is useful for the distinguish between MPLC and IM.For MPLC,surgery remains the main treatment modality.For inoperable MPLC,radiotherapy and local ablation are important treatments.NGS and new therapies such as targeted drug therapy and immune checkpoint inhibitors have become new altenatives for the diagnosis and treatment of MPLC.This article reviews recent advances in the diagnosis and treatment of MPLC.