文献类型：期刊文献

英文题名：All-in-one hyperbranched polypeptides for surgical adhesives and interventional embolization of tumors

作者：Lu, Dedai[1];Li, Yunfei[1];Wang, Xiangya[1];Li, Ting'e[1];Zhang, Yongyong[1];Guo, Hongyun[2];Sun, Shaobo[3];Wang, Xiaoqi[2];Zhang, Yongdong[2];Lei, Ziqiang[1]

第一作者：Lu, Dedai

通信作者：Lu, DD[1]

机构：[1]Northwest Normal Univ, Key Lab Ecoenvironm Related Polymer Mat, Coll Chem & Chem Engn, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China;[2]Gansu Prov Canc Hosp, Inst Gansu Med Sci Res, Lanzhou 730050, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Northwest Normal Univ, Key Lab Ecoenvironm Related Polymer Mat, Coll Chem & Chem Engn, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China

通信机构：[1]corresponding author), Northwest Normal Univ, Key Lab Ecoenvironm Related Polymer Mat, Coll Chem & Chem Engn, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China.

年份：2018

卷号：6

期号：45

起止页码：7511

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20184806143307);Scopus(收录号：2-s2.0-85057136719);WOS:【SCI-EXPANDED(收录号:WOS:000451073100019)】；

基金：This work was supported in part by the National Natural Science Foundation of China (No. 51103118, 21865029), the Research Project of Universities of Gansu Province (2015A-005), Innovation Team Project of NWNU (NWNU-LKQN-16-02) and Longyuan Youth Innovation and Entrepreneurial Talents Project. We also thank Key Laboratory of Eco-environment-related Polymer Materials Ministry of Education, Key Lab of Polymer Materials of Gansu Province, for financial support.

语种：英文

外文关键词：Adhesion - Adhesives - Bond strength (materials) - Bone - Surgery

摘要：A series of hyperbranched, thermo-responsive and mussel-inspired polypeptides were synthesized and used for surgical adhesion, hemostasis and interventional embolization. These polypeptides showed excellent tissue-adhesive properties according to adhesive strength tests on porcine skin and bone in vitro, where the maximum lap-shear adhesion strength on porcine skin was 114.5 kPa and the maximum tensile adhesion strength on bone was 786 kPa. In vivo animal experiments indicated that these polypeptides exhibit superior hemostatic properties and healing effects in skin incisions and osteotomy gap; the skin incision healing and osteotomy gap remodeling were completed in all rats after 14 and 60 days, respectively. In vivo evaluation of the embolization ability of these polypeptides was performed on rabbit kidney models, resulting in successful occlusion of renal arteries, which led to gross ischemic changes in the embolized kidneys up to 16 days. A trial embolization procedure on H22 tumor-bearing rat models also confirmed the gelability of these polypeptides in tumor arteries, which might cause damage to embolized tumors. Therefore, these polypeptides are expected to be good candidates as surgical tissue adhesives, antibleeding materials, and effective embolic materials.