文献类型：期刊文献

英文题名：MiR-19a-3p: a potential biomarker for predicting cardiac risk in anderson-fabry disease

作者：Zhang, Yiming[1,2,3,4];Yang, Hongqiang[5];Wang, Shuping[1,2,3,4];Yi, Chengcheng[1,2,3,4];Wang, Yongxiang[1,2,3,4];Bai, Ming[1,2,3,4];Zhang, Zheng[1,2,3,4]

第一作者：Zhang, Yiming

通信作者：Zhang, Z[1];Zhang, Z[2];Zhang, Z[3];Zhang, Z[4]

机构：[1]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Hosp 1, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Hosp 1, Gansu Key Lab Cardiovasc Dis, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou Univ, Hosp 1, Gansu Clin Med Res Ctr Cardiovasc Dis, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Hosp 1, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Lanzhou Univ, Hosp 1, Gansu Key Lab Cardiovasc Dis, Lanzhou 730000, Gansu, Peoples R China;[4]corresponding author), Lanzhou Univ, Hosp 1, Gansu Clin Med Res Ctr Cardiovasc Dis, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2026

卷号：21

期号：1

外文期刊名：JOURNAL OF CARDIOTHORACIC SURGERY

收录：;Scopus(收录号：2-s2.0-105049247854);WOS:【SCI-EXPANDED(收录号:WOS:001866751100001)】；

基金：This study was funded by the in-house fund of Lanzhou University First Hospital (Fund number: ldyyyn2023-38) and Natural Science Foundation of Gansu Province (Fund No. 24JRRA294).

语种：英文

外文关键词：MiR-19a-3p; AFD; Cardiac damage; Biomarker

摘要：Background MicroRNAs(miRNAs) have been shown to suppress the onset and progression of heart disease and have recently been widely proposed as biomarkers. However, few literatures have been reported on whether they protect against Anderson-Fabry-induced myocardial damage.Objective The aim was to explore whether miR-19a-3p could be used as a biomarker for the diagnosis and risk assessment of Anderson-Fabry disease (AFD), distinguishing AFD from healthy controls and myocardial damage caused by AFD.Methods 60 AFD patients and an equal number of healthy controls were recruited to analyze miR-19a-3p expression. ROC analysis evaluated their diagnostic ability, and statistical analysis demonstrated the association of clinical indicators of cardiac damage with miR-19a-3p.Results 53.3% of AFD patients exhibited cardiac damage, with notable structural changes in cardiac characteristics. MiR-19a-3p expression level was downregulated in AFD and AFD cardiomyopathy patients and showed high diagnostic accuracy for identifying both AFD and associated cardiac injury. It negatively correlated with severity of cardiac injury. Multivariate analysis identified miR-19a-3p as a significant independent protective factor in cardiac damage in AFD.Conclusion The study identified downregulated miR-19a-3p as a potent diagnostic biomarker for AFD and its associated cardiomyopathy. MiR-19a-3p was established as an independent protective factor in cardiac damage. Thus, it was proposed as a promising candidate biomarker for AFD cardiomyopathy.