文献类型：期刊文献

英文题名：A review of respirable fine particulate matter (PM_2.5)-induced brain damage

作者：Li, Wei[1,2,3];Lin, Guohui[4];Xiao, Zaixing[2,3];Zhang, Yichuan[2,3];Li, Bin[2,3];Zhou, Yu[3,5];Ma, Yong[2,3];Chai, Erqing[2,3]

第一作者：Li, Wei;李伟

通信作者：Chai, EQ[1];Chai, EQ[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Peoples Hosp, Cerebrovasc Dis Ctr, Lanzhou, Peoples R China;[3]Key Lab Cerebrovasc Dis Gansu Prov, Lanzhou, Peoples R China;[4]Day Treatment Ctr II Gansu Prov Matern & Child Ca, Lanzhou, Peoples R China;[5]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Cerebrovasc Dis Ctr, Lanzhou, Peoples R China;[2]corresponding author), Key Lab Cerebrovasc Dis Gansu Prov, Lanzhou, Peoples R China.

年份：2022

卷号：15

外文期刊名：FRONTIERS IN MOLECULAR NEUROSCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000859690200001)】；

语种：英文

外文关键词：respirable fine particulate matter (PM2.5); brain injury; mechanism; review; self-repair of brain injury

摘要：Respirable fine particulate matter (PM2.5) has been one of the most widely publicized indicators of pollution in recent years. Epidemiological studies have established a strong association between PM2.5, lung disease, and cardiovascular disease. Recent studies have shown that PM2.5 is also strongly associated with brain damage, mainly cerebrovascular damage (stroke) and neurological damage to the brain (changes in cognitive function, dementia, psychiatric disorders, etc.). PM2.5 can pass through the lung-gas-blood barrier and the "gut-microbial-brain" axis to cause systemic oxidative stress and inflammation, or directly enter brain tissue via the olfactory nerve, eventually damaging the cerebral blood vessels and brain nerves. It is worth mentioning that there is a time window for PM2.5-induced brain damage to repair itself. However, the exact pathophysiological mechanisms of brain injury and brain repair are not yet fully understood. This article collects and discusses the mechanisms of PM2.5-induced brain injury and self-repair after injury, which may provide new ideas for the prevention and treatment of cerebrovascular and cerebral neurological diseases.