文献类型：期刊文献

英文题名：A Synergistic Sonosensitive Pyroptosis Nanoactivator for Efficient Lung Adenocarcinoma Therapy

作者：Duan, Yanqiu[1];Song, Xinran[2];Ye, Wenting[1];Zhu, Ying[1];Li, Meng[3];Liu, Lili[4];Fu, Hao[2];Wang, Lei[5];Chen, Yu[4];Chang, Meiqi[1]

第一作者：Duan, Yanqiu

通信作者：Chang, MQ[1];Chen, Y[2];Wang, L[3]

机构：[1]Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Sci & Technol Innovat Ctr, Shanghai, Peoples R China;[2]Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr,Guangdong Hong Kong Joint Lab RNA Med, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China;[3]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Peoples R China;[4]Shanghai Univ, Sch Life Sci, Materdicine Lab, Shanghai, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Med, Shanghai Chest Hosp, Dept Ultrasound, Shanghai, Peoples R China

第一机构：Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Sci & Technol Innovat Ctr, Shanghai, Peoples R China

通信机构：[1]corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Sci & Technol Innovat Ctr, Shanghai, Peoples R China;[2]corresponding author), Shanghai Univ, Sch Life Sci, Materdicine Lab, Shanghai, Peoples R China;[3]corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Chest Hosp, Dept Ultrasound, Shanghai, Peoples R China.

年份：2026

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20263921551104);Scopus(收录号：2-s2.0-105051575763);WOS:【SCI-EXPANDED(收录号:WOS:001884467100001)】；

基金：Shanghai Science and Technology Committee Rising-Star Program (Grant no. 24QA2708600), Shanghai Young Talent Program of Eastern Talent Plan (Grant no. QNWS2024006), Wenzhou Basic Scientific Research Project (Grant no. Y20240112), China National Postdoctoral Program for Innovative Talents (Grant no. BX2026202), Yat-sen Postdoctoral Grow-up Program and Guangdong Basic and Applied Basic Research Foundation (Grant no. 2025A1515220156).

语种：英文

外文关键词：covalent organic framework; nanomedicine; nanozyme; pyroptosis; sonodynamic therapy; synergistic therapy

摘要：The critical challenge of apoptosis resistance severely constrains the efficacy of conventional cancer therapies. To address this issue, this study turns to pyroptosis, a lytic cell death pathway, and develops a novel therapeutic strategy by repurposing triptolide (TPL), a natural compound from traditional Chinese medicine (TCM), as a potent pyroptosis inducer. We rationally co-load TPL with the sonosensitizer rose bengal (RB) into a customized covalent organic framework (COF) to construct a synergistic nanoplatform (CRT). The "old drug, new trick" paradigm is potentiated by a nanomaterial-mediated synergistic mechanism: US-triggered reactive oxygen species (ROS) generation from RB orchestrates a dual action, simultaneously inducing direct mitochondrial damage and initiating the controlled release of TPL. This dual action creates a feed-forward loop that drives the progressive amplification of cytotoxic signals from both agents, culminating in the cooperative and robust activation of caspase-3/GSDME-mediated pyroptosis. Consequently, this CRT platform effectively circumvents apoptotic resistance, demonstrating tumor-selective accumulation, potent antitumor efficacy in lung cancer models, and a highly favorable biosafety profile. This work establishes a precise and noninvasive nanomedicine paradigm, highlighting how advanced biomaterial design can unlock the synergistic potential of repurposed drugs for next-generation cancer therapy.