文献类型：期刊文献

中文题名：子宫内膜异位症程序性细胞死亡和中医药干预作用研究进展

英文题名：Programmed Cell Death in Endometriosis and Traditional Chinese Medicine Intervention:A Review

作者：张作良[1];王婉润[1];李雯[2];韩雪[2];陈晓红[2];苏楠[2];刘会玲[2];武权生[1]

第一作者：张作良

机构：[1]甘肃中医药大学中医临床学院,兰州730000;[2]甘肃省人民医院,兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：31

期号：4

起止页码：48

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金项目(82260949);甘肃省自然科学基金项目(3JRRA11992);甘肃省中医药科研项目(GZKD-2022-22);兰州市科技计划项目(2021-1-97,2023-ZD-21);甘肃省人民医院院内科研基金项目(24GSSYE-12)。

语种：中文

中文关键词：子宫内膜异位症;程序性细胞死亡;中医药;凋亡;焦亡;自噬;铁死亡;铜死亡

外文关键词：endometriosis;programmed cell death;traditional Chinese medicine;apoptosis;pyroptosis;autophagy;ferroptosis;cuproptosis

摘要：子宫内膜异位症(EMT)是现代妇产科临床常见病、多发病、疑难病,该病以进行性加重的痛经、盆腔包块、不孕等为主要临床表现。EMT发病率不断升高且呈年轻化趋势,严重危害育龄期及青春期女性生殖、心理健康。但EMT发病机制尚不完全明确,病程缠绵难愈,因此寻找新的治疗策略是临床亟需解决的问题。目前中医药治疗EMT取得长足发展,但对其作用机制的研究仍处于探索阶段。程序性细胞死亡(PCD)是由多种生物分子协调介导的、具有特定信号级联反应细胞死亡模式,目前已知的PCD过程主要包括凋亡、焦亡、自噬、铁死亡、铜死亡等,均在EMT的发生发展中起着举足轻重的作用。中医药调控PCD多途径、多通路、多靶点、多机制的策略治疗EMT方面取得了一定的进展,但目前尚缺乏中医药调控PCD治疗EMT总结性综述。该文基于凋亡、焦亡、自噬、铁死亡、铜死亡等5种PCD过程对中医药治疗EMT的研究进展进行梳理,以期为临床防治EMT提供一定的理论依据。
Endometriosis(EMT)is a common disease with frequent occurrence and difficult to be cured in modern clinical practice of obstetrics and gynaecology.It is characterized by progressively worsening dysmenorrhoea,pelvic mass,and infertility.The incidence of EMT is growing and increasingly younger patients are diagnosed with this disease,which poses a serious threat to the reproductive and psychological health of women of childbearing age and adolescent females.However,the pathogenesis of EMT is still not completely clear,and the disease has a long course.Therefore,developing new therapies is an urgent clinical problem to be solved.Great progress has been achieved in the treatment of EMT with traditional Chinese medicine(TCM),while the underlying mechanism remains in exploration.Programmed cell death(PCD)is a cell death mode mediated by a variety of biomolecules with specific signaling cascades.The known PCD processes include apoptosis,pyroptosis,autophagy,ferroptosis,and cuproptosis,which all play a pivotal role in the development of EMT.Researchers have made achievements in the treatment of EMT with TCM,which regulates PCD via multiple pathways,routes,targets,and mechanisms.However,the progress in the regulation of PCD in the treatment of EMT with TCM remains to be reviewed.This paper reviews the research progress in the treatment of EMT with TCM from five PCD processes(apoptosis,pyroptosis,autophagy,ferroptosis,and cuproptosis),with the aim of providing a theoretical basis for the clinical prevention and treatment of EMT.