文献类型：期刊文献

中文题名：消化系统病证结合动物模型的研究进展及中医药靶点干预

英文题名：Research Progress of Digestive System Disease and Syndrome Combined Animal Model andTraditional Chinese Medicine Target Intervention:A Review

作者：胥文娟[1,2];汪龙德[3];牛媛媛[1];毛兰芳[3];杜晓娟[1];张萍[1]

第一作者：胥文娟

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省中医院,兰州730050;[3]甘肃中医药大学附属医院,兰州730020

第一机构：甘肃中医药大学

年份：2022

卷号：28

期号：19

起止页码：258

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金项目(82160883);甘肃省科技厅自然基金项目(21JR11RA210);敦煌医学与转化教育部重点实验室开放课题(DHYX18-27);兰州市科技局项目(2018-3-42)。

语种：中文

中文关键词：病证结合;动物模型;反流性食管炎;非酒精性脂肪性肝病;功能性消化不良

外文关键词：combination of disease and syndrome;animal model;reflux esophagitis;nonalcoholic fatty liver disease;functional dyspepsia

摘要：反流性食管炎(肝胃不和证、痰气交阻证、气滞血瘀证、浊毒内蕴证)、非酒精性脂肪性肝病(肝郁脾虚证、痰瘀互结证、湿热内蕴证、痰湿内阻证)及功能性消化不良(肝郁脾虚证、肝胃不和证、脾胃虚寒证、寒热错杂证)是消化系统的常见病与多发病,病程迁延且患病率较高。病证结合动物模型的成功建立是探索中医药效应机制的前提及新型制剂开发的基础,同时掌握“病-证-方”三者之间的复杂关系网络是治疗获效的先决条件。当不同疾病间出现相同证候时,中医学“异病同治”理念提示可针对部分证候模型短缺情况进行方法互参。中医药干预消化系统疾病具有多途径、多靶点、多维度、多层次等特点。因此,该文通过文献梳理,总结反流性食管炎、非酒精性脂肪性肝病及功能性消化不良等疾病的常见病证结合模型的操作方法及中医药干预机制,以期为消化系统疾病不同证型的客观化研究提供理论依据,并为传统中医药方剂的基础研究及成果转化提供方法学指导。
Reflux esophagitis(liver-stomach disharmony,Spittoon-Qi interties,Qi and blood stasis syndrome,turbid poison intrinsic)and nonalcoholic fatty liver disease(liver depression,spleen deficiency,phlegm and blood stasis syndrome,hot and humid embodiment,phlegmy wet resistance)and functional dyspepsia(liver depression syndrome,liver stomach with spleen deficient,spleen deficiency cold syndrome,in a word,fever)is a common disease and frequently encountered disease of digestive system.The course of disease is prolonged and the prevalence is high.The successful establishment of animal model combining disease and syndrome is the premise of exploring the mechanism of traditional Chinese medicine(TCM)effect and the foundation of the development of new preparations.At the same time,mastering the complex relationship network among disease,syndrome and prescription is the prerequisite of effective treatment.When the same syndrome occurs between different diseases,the concept of"treating different diseases with the same treatment"in TCM suggests that methods can be cross-referenced for the shortage of some syndrome models.TCM intervention of digestive diseases has the characteristics of multi-path,multi-target,multi-dimension and multilevel.Therefore,this article through the literature review,summarizes the reflux esophagitis,nonalcoholic fatty liver disease and functional dyspepsia is a common disease such as the combined operation method of the model and the intervention mechanism of TCM,so as to diseases of the digestive system of different syndrome types provides the theory basis for the objective of research,and the basic research of TCM prescription and achievements provide methodological guidance.