文献类型：期刊文献

英文题名：Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment

作者：Si, Xiao-Li[1,2];Wang, Yan[2,3];Song, Bo-Ni[4];Zhang, Yan[1];Yang, Qing-Xia[1];Li, Zhi[4];Luo, Yan-Ping[1];Duan, Yong-Qiang[2,5];Ma, Xing-Ming[1];Zhang, Yan-Ying[6]

第一作者：Si, Xiao-Li;司晓丽

通信作者：Ma, XM[1];Zhang, YY[2]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Dept Immunol, 199 West Donggang Rd, Lanzhou 730030, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med Sci, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China;[3]Ningxia Med Univ, Sch Tradit Chinese Med, 1160 Victory St, Yinchuan 750004, Ningxia, Peoples R China;[4]Lanzhou Univ Technol, Sch Life Sci & Engn, 287 LanGongPing Rd, Lanzhou 730050, Peoples R China;[5]Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat, Minist Educ, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China;[6]Gansu Univ Chinese Med, Sci Res & Expt Ctr, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Dept Immunol, 199 West Donggang Rd, Lanzhou 730030, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Dept Immunol, 199 West Donggang Rd, Lanzhou 730030, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sci Res & Expt Ctr, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China.|[107359c91a78c5fd2e803]甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）;[10735]甘肃中医药大学;

年份：2022

卷号：19

期号：8

外文期刊名：CHEMISTRY & BIODIVERSITY

收录：;Scopus(收录号：2-s2.0-85136820301);WOS:【SCI-EXPANDED(收录号:WOS:000837201200001)】；

基金：We thank Wan-Rong Kang and Jiao Yang for their technical guidance in making animal models and Xiao-wen Guan and Yuan-Yuan Zhang for their assistance in drug intervention and tissue specimen collection. We also thank Ai-Jun Yang and Wei Liu for their analysis and guidance regarding the histopathological sections. Lastly, we thank Bao-Ke Han and Beijing Yetech Technology Co., Ltd. for their support and assistance with the pathological sections.

语种：英文

外文关键词：network pharmacology; molecular docking; paeoniflorin; colitis-associated colorectal cancer; IL-6; STAT3

摘要：Chronic inflammation plays a positive role in the development and progression of colitis-associated colorectal cancer (CAC). Medicinal plants and their extracts with anti-inflammatory and immunoregulatory properties may be an effective treatment and prevention strategy for CAC. This research aimed to explore the potential chemoprevention of paeoniflorin (PF) for CAC by network pharmacology, molecular docking technology, and in vivo experiments. The results showed that interleukin-6 (IL-6) is a key target of PF against CAC. In the CAC mouse model, PF increased the survival rate of mice and decreased the number and size of colon tumors. Moreover, reduced histological score of colitis and expression of Ki-67 and PCNA were observed in PF-treated mice. In addition, the chemoprevention mechanisms of PF in CAC may be associated with suppression of the IL-6/STAT3 signaling pathway and the IL-17 level. This research provides experimental evidence of potential chemoprevention strategies for CAC treatment.