文献类型：期刊文献

中文题名：免疫调节在肿瘤中的病理机制及中药干预的研究现状

英文题名：Research status of the pathological mechanisms of immune regulation in tumors and the intervention of traditional Chinese medicine

作者：汪学鹏[1];郭昊铭[1];师亮亮[1];王帅哲[1];陈亚萍[1];魏本君[1,2]

第一作者：汪学鹏

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学甘肃省中医方药挖掘与创新转化重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2024

卷号：40

期号：20

起止页码：3051

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金资助项目(8226150420)。

语种：中文

中文关键词：中药防护;免疫调节;肿瘤

外文关键词：traditional Chinese medicine protection;immunoregulation;tumor

摘要：肿瘤的发生和发展与机体的免疫功能密切相关,已被证实免疫疗法在各种癌症治疗中具有作用。从中药提取出的多糖类化合物、生物碱类化合物、皂苷类化合物、黄酮类化合物及复方通过多点显效发挥作用近年来在肿瘤领域备受关注,通过增强机体抗肿瘤免疫力来控制肿瘤的生长和转移。即使在免疫抑制的肿瘤微环境中,中药也可以通过上调免疫反应来发挥抗肿瘤作用。本文旨在从免疫调节在肿瘤中的作用机制出发,综述其在肿瘤中的机制及中药通过调节机体免疫功能发挥抗肿瘤作用,为中药在肿瘤防治中提供理论参考。
The occurrence and development of tumors are closely related to the body's immune function.It has been confirmed that immunotherapy plays a role in the treatment of various cancers.Some traditional Chinese medicines can control the growth and metastasis of tumors by enhancing anti-tumor immunity.Even in the immunosuppressive tumor microenvironment,traditional Chinese medicine can exert anti-tumor effects by upregulating immune responses.Further research on the regulation of the immune mechanisms by traditional Chinese medicine will provide new insights into how traditional Chinese medicine controls tumor growth and metastasis and help improve its effectiveness in the clinical treatment of various cancers.This article aims to provide a theoretical reference for the role of immunoregulation in tumors,summarize its mechanisms in tumors,and traditional Chinese medicine intervention research in tumors for the prevention and treatment of tumors with traditional Chinese medicine.