文献类型：期刊文献

中文题名：基于铁死亡理论的中医药防治肿瘤研究进展

英文题名：Chinese Medicine Prevention and Treatment of Tumor Based on Ferroptosis:A Review

作者：张启立[1];赵磊[1,2,3,4];夏鹏飞[1,3,4];武晓玉[1];续艳丽[1,2];彭雪晶[1];杨飞霞[1];边惠琴[1];李娇娇[1]

第一作者：张启立

机构：[1]甘肃中医药大学,兰州730000;[2]兰州市食品药品检验检测研究院,兰州730000;[3]甘肃省高校中藏药化学与质量研究省级重点实验室,兰州730000;[4]甘肃省道地药材质量标准化技术研究与推广工程实验室,兰州730000

第一机构：甘肃中医药大学

年份：2021

卷号：27

期号：22

起止页码：222

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金项目(82160457,81660577);甘肃省青年科技基金计划项目(20JR5RA175);甘肃省自然科学基金项目(21JR7RA564);甘肃省教育厅“双一流”科研重点项目(GSSYLXM-05)。

语种：中文

中文关键词：铁死亡;信号通路;作用机制;中医药;肿瘤防治

外文关键词：ferroptosis;signaling pathway;mechanism;Chinese medicine;tumor prevention and treatment

摘要：铁死亡是指在铁离子的参与下,因铁依赖性活性氧的异常堆积而导致氧化还原平衡失调而引起的一种新型细胞死亡方式。近年来研究发现铁死亡与多种疾病的发生存在一定关联,尤其对于肿瘤的发生发展具有一定的调节作用。中医药在肿瘤的防治过程中具有独特优势,如何利用铁死亡理论指导中医药有效防治癌症等肿瘤类疾病是该领域新的研究热点。该文从铁死亡理论的提出、作用机制和信号通路,肿瘤治疗中的应用及基于铁死亡理论的中药活性研究等方面进行了整理和总结,发现铁死亡的发生与铁代谢、脂质活性氧代谢等多种信号通路及基因的表达有关,铁死亡在肿瘤的发生发展、治疗、以及肿瘤免疫中都发挥着重要的调控作用,这将为肿瘤的治疗和抗癌药物的研发提供了策略。同时对中药干预铁死亡发挥生物活性的整理发现,诸如黄芩、葛根、黄芪、银杏、淫羊藿、青蒿、丹参等多味中药,脑泰方、四君子汤、参麦注射液等中药复方,以及黄芩素、双氢青蒿素、葛根素、荜茇酰胺、木犀草素、槲皮素等多种中药有效成分,均能够通过调节铁死亡发挥抗肿瘤等生物活性。可见,中药在通过调控铁死亡防治肿瘤等疾病方面潜力巨大。该文为铁死亡理论的深入研究及指导中医药防治肿瘤类疾病等方面提供理论依据和研究思路。
Ferroptosis is a new type of cell death caused by abnormal accumulation of iron-dependent reactive oxygen species(ROS)and imbalance of redox with the participation of iron ions. In recent years,studies have found that ferroptosis is associated with various diseases and can especially regulate the development of tumors. Chinese medicine has unique advantages in tumor prevention and treatment. How to use ferroptosis theory to guide the prevention and treatment of cancer and other tumor diseases by Chinese medicine is a new research hotspot. This paper summarizes the proposal,action mechanism,and signaling pathway of ferroptosis,its application in tumor therapy,and the research on the activity of Chinese medicine based on ferroptosis. Results found that the occurrence of ferroptosis is related to iron metabolism,lipid ROS metabolism,and other signaling pathways and gene expressions. Ferroptosis can regulate tumor initiation and development,treatment,and tumor immunity,which provides strategies for tumor treatment and anti-tumor drug development.By analyzing the biological activity of Chinese medicine against ferroptosis,we found that Chinese medicines(Scutellariae Radix,Puerariae Lobatae Radix,Astragali Radix,Ginkgo,Epimedii Folium,Artemisiae Annuae Herba,and Salviae Miltiorrhizae Radix et Rhizoma),Chinese herbal compounds( Naotaifang,Si Junzitang,and Shenmai injection),and Chinese medicine effective components(baicalein,dihydroartemisinin,puerarin,piperlongumine, luteolin, and quercetin) can exert antitumor and other biological activities by regulating ferroptosis. Therefore,Chinese medicine has great potential in preventing and controlling tumors and other diseases by regulating ferroptosis. This paper provides theoretical basis and research ideas for the in-depth study of ferroptosis theory and guides the prevention and treatment of tumor diseases by Chinese medicine.