文献类型：期刊文献

英文题名：Advances in the Understanding of Mitochondrial Inflammatory Regulation in the Pathogenesis of Alzheimer's Disease

作者：Zhang, Ren-Zhen[1];Li, Li[1];Ma, Cui[1];Dou, Ting-Ting[1];Wei, Yu-Ting[1];Yan, Xing-Ke[1,2]

第一作者：Zhang, Ren-Zhen

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Lanzhou, Peoples R China;[2]Gansu Prov Tradit Chinese Med Res Ctr, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Acupuncture & moxibust & Massage Coll, 35 Dingxi East Rd, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：18

起止页码：14475

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;Scopus(收录号：2-s2.0-105019697223);WOS:【SCI-EXPANDED(收录号:WOS:001600579100001)】；

基金：This work was supported by Gansu Provincial Higher Education Institutions Scientific Research Project (Project No.: 2018C-18); the Special Open Project of Gansu Provincial Traditional Chinese Medicine Research Center in 2024 (zyzx-2024-zx03, zyzx-2024-zx09); the 2024 University Teacher Innovation Fund Project (2024A-082); the Gansu University of Traditional Chinese Medicine Talent Introduction and Research Launch Fund Project (2024YJRC-06).

语种：英文

外文关键词：Alzheimer's disease; mitochondrion; neuroinflammation; inflammatory mechanism; review

摘要：Mitochondria, beyond serving as the powerhouse of the cell, play a pivotal role in the regulation of inflammatory responses. Mitochondrial dysfunction-induced immune activation and chronic inflammation are deeply implicated in the pathogenesis of Alzheimer's disease (AD), influencing its onset and progression through multiple inflammatory pathways. This review summarizes the involvement of several mitochondrial-related mechanisms in AD, including the release of mitochondrial DNA (mtDNA), signal transduction via mitochondrial antiviral-signaling protein (MAVS), the accumulation of mitochondrial damage-associated molecular patterns (DAMPs), the regulation of mitophagy, and the activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. These insights aim to shed new light on mitochondrial inflammation as a regulatory mechanism in AD and to explore its potential as a therapeutic target.