文献类型：期刊文献

英文题名：Targeting tumor-associated macrophage polarization with traditional Chinese medicine active ingredients: Dual reversal of chemoresistance and immunosuppression in tumor microenvironment

作者：Qi, Yafeng[1];Yan, Jingnan[1];Huang, Xixi[1];Jiang, Xiaodan[1];Li, Rongrong[1];Wan, Jiayi[1];Li, Yangyang[1];Miao, Zhiming[1];Song, Zhongyang[1];Liu, Yongqi[1,2,3];Zhang, Liying[1,3];Zhang, Zhiming[4]

第一作者：Qi, Yafeng

通信作者：Liu, YQ[1];Zhang, LY[1];Zhang, ZM[2]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Minister, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[4]Gansu Prov Hosp Tradit Chinese Med, Dept Oncol, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), 418 Guazhou Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2025

卷号：216

外文期刊名：PHARMACOLOGICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-105005832216);WOS:【SCI-EXPANDED(收录号:WOS:001504618900001)】；

基金：This work was supported by the Natural Science Foundation of Gansu Province (Grant No. 24JRRA570) ; The Science and Technology Program of Gansu Province (Grant No. 18JR2FA001) ; National Natural Science Foundation of China (Grant No. 81160882) .

语种：英文

外文关键词：Natural product; Tumor-associated macrophage (TAM); Chemoresistance; Immunosuppression; Therapeutic potential

摘要：Chemotherapy resistance and immunosuppression are major causes of tumor treatment failure. The polarization state of tumor-associated macrophages (TAMs) is a central regulatory hub for both processes. Traditional Chinese medicine (TCM) has the characteristics of multi-component, multi-target, and multi-pathway. It regulating M1/ M2 polarization is promising due to the high plasticity of TAMs. This review comprehensively explores the antitumor effects of TCM active components through multiple targets such as metabolic reprogramming. The mechanism includes regulating TAM's polarization, reversing chemotherapy resistance, and modulating immunosuppression. Furthermore, we also summarize the synergistic effects of TCM multi-component and the exploration of mechanisms promoted by new technologies. While most studies are still in the preclinical stage, these insights highlight the potential of TCM as a cancer treatment and highlight avenues for future research and clinical application to improve patient outcomes.