文献类型：期刊文献

英文题名：Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease

作者：Li, Botong[1,2];Wang, Yixuan[3,4];Jiang, Xiaolin[1,2];Du, Hongwei[5];Shi, Yan[1,2];Xiu, Minghui[3,4];Liu, Yongqi[1,4];He, Jianzheng[1,2,4]

第一作者：Li, Botong

通信作者：Liu, YQ[1];He, JZ[1];Xiu, MH[2]

机构：[1]Gansu Univ Chinese Med, Prov level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial L, Lanzhou 730000, Peoples R China;[5]Gansu Univ Polit Sci & Law, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2023

卷号：164

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;Scopus(收录号：2-s2.0-85160421736);WOS:【SCI-EXPANDED(收录号:WOS:001011535600001)】；

基金：Funding The authors appreciated the financial support received from the National Natural Science Foundation of China (Nos. 82104562, 81960793) , Gansu Longyuan Youth Talent Innovation and Entrepre-neurship Project, Fundation of Gansu Provincial Administration of Traditional Chinese Medicine (No. GZKZ-2022-9) .

语种：英文

外文关键词：Nrf2; ARE signaling pathway; Inflammatory bowel disease; Nature compounds; Natural extract; Compound recipe; Gut microbe

摘要：Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a complex process that regulated by multiple signaling pathways, including nuclear factor erythroid 2-related factor (Nrf2)/ antioxidant response element (ARE) signaling pathway. Nrf2/ARE pathway as the central defense mechanism against oxidative stress controls the expression of many antioxidant and anti-inflammatory genes in the nucleus, and plays a crucial role in the treatment of IBD. Various studies have proved that many natural compounds target Nrf2/ARE signaling pathway to treat IBD. Here, we introduced the regulatory mechanism of the Nrf2/ARE pathway, and its role in IBD and IBD complications (intestinal fibrosis and colorectal cancer (CRC)); summarized the research progress of Nrf2 targeted natural compounds and extracts in the treatment of IBD; and finally described the intestinal microbiota that alleviate or treat IBD via activating Nrf2/ARE signaling pathway. This review highlights the potential for targeting Nrf2/ARE pathway to treat IBD.