文献类型：期刊文献

英文题名：Unlocking nature's medicine cabinet through Drosophila-Driven exploration

作者：Sheng, Xiao[1];He, Jianzheng[3,4];Zhang, Lei[1,2]

第一作者：Sheng, Xiao

通信作者：Zhang, L[1];Zhang, L[2];He, JZ[3];He, JZ[4]

机构：[1]Naval Med Univ, Dept Pharmaceut Bot, Sch Pharm, Shanghai 200433, Peoples R China;[2]Zhejiang Sci Tech Univ, Innovat Drug Res Ctr, Sch Life Sci & Med, Hangzhou 310018, Peoples R China;[3]Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou 730000, Peoples R China;[4]Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China

第一机构：Naval Med Univ, Dept Pharmaceut Bot, Sch Pharm, Shanghai 200433, Peoples R China

通信机构：[1]corresponding author), Naval Med Univ, Dept Pharmaceut Bot, Sch Pharm, Shanghai 200433, Peoples R China;[2]corresponding author), Zhejiang Sci Tech Univ, Innovat Drug Res Ctr, Sch Life Sci & Med, Hangzhou 310018, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou 730000, Peoples R China;[4]corresponding author), Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China.|[107359c91a78c5fd2e803]甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）;[10735]甘肃中医药大学;

年份：2025

卷号：146

外文期刊名：PHYTOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001580361800025)】；

基金：We express our admiration and regard for the dedication and hard work of field and laboratory researchers. We extend our apologies to the scientists whose papers are not mentioned due to space constraints. This work was supported by the National Natural Science Foundation of China (No. 82225047 and 32170274) , the National Key Research and Development Program of China (No. 2022YFC3501703) , the Gansu Natural Science Foundation (No. 23JRRA1202) , and the Naval Medical University Campus Project (No. 2023QN025) . We thank LetPub ( www.letpub.com .cn) for its linguistic assistance during the preparation of this manuscript.

语种：英文

外文关键词：Drosophila melanogaster; Natural products pharmacology; High-throughput screening; Therapeutic mechanisms; Preclinical validation; Drug discovery

摘要：Background: Bioactive natural compounds have made significant contributions to health and medicine due to their therapeutic properties, yet they remain a vastly untapped resource in the quest for novel therapeutic agents. Drosophila melanogaster is a powerful model organism in biomedicine, offering a versatile platform for genetic and pharmacological studies. Despite their proven value, Drosophila models in the primary screening of natural products for drug discovery and clinical practices remain underutilized. Purpose: This review elucidates the utility, effectiveness, and unique advantages of Drosophila as a model for exploring natural products in disease treatment, with the objective of demonstrating how Drosophila models provide new insights into the action mechanisms of natural products and aid in their therapeutic development. Methods: Drosophila models in drug discovery were the focus of this study, including phenotypic approaches, genetic tools, advanced technologies, and available resources. A systematic literature review was performed via PubMed (2015-2025) using the keywords: "Drosophila," "natural products," "compound," "medicine," "drug," and "specific human disease model based on Drosophila." Boolean operators (AND/OR) were used to refine searches, and PRISMA guidelines were followed to ensure methodological rigor. Results: The analysis revealed that Drosophila models in natural product screening offer reproducible phenotypic readouts, well-established genetic tools, and cost effectiveness. Comprehensive Drosophila model resources and successful applications across various disease contexts are highlighted. Conclusion: This review establishes a refined framework for using Drosophila in high-throughput screening of natural product libraries to promote its systematic integration into natural product drug discovery pipelines.